Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Introduction to WikiPathways (slides)
WikiPathways Overview or New Contributor Quickstart
General help pages
CPTAC Workshop Exercises

Resources

Learn more about CPTAC
Pathway analysis
- Cytoscape and the WikiPathways app
- PathVisio and the WikiPathways plugin

Curation projects

Curating Hallmark Pathways -- How to
Example: construction of Pathways in Renal Cancer
Contact Alex Pico if interested in curating, adding or using CPTAC pathways, apico@gladstone.ucsf.edu

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Cancer Hallmark Categories

Sustaining proliferative signaling FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma (Homo sapiens) Image does not exist FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma	Evading growth suppressors Tumor suppressor activity of SMARCB1 (Homo sapiens) Image does not exist Tumor suppressor activity of SMARCB1	Activating invasion and metastasis Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens) Image does not exist Epithelial to mesenchymal transition in colorectal cancer
Enabling replicative immortality ncRNAs in Wnt signaling in hepatocellular carcinoma (Homo sapiens) Image does not exist ncRNAs in Wnt signaling in hepatocellular carcinoma	Inducing angiogenesis MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors (Homo sapiens) Image does not exist MSMP expression regulation in cancer cells and its pro-angiogenic role in ovarian tumors	Resisting cell death Apoptosis (Homo sapiens) Image does not exist Apoptosis
Deregulating cellular energetics Fatty acid beta-oxidation (Homo sapiens) Image does not exist Fatty acid beta-oxidation	Genome instability and mutation ATR signaling (Homo sapiens) Image does not exist ATR signaling	Tumor promoting inflammation IL6 signaling (Homo sapiens) Image does not exist IL6 signaling
Avoiding immune destruction Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens) Image does not exist Altered glycosylation of MUC1 in tumor microenvironment	Therapeutics MicroRNA for targeting cancer growth and vascularization in glioblastoma (Homo sapiens) Image does not exist MicroRNA for targeting cancer growth and vascularization in glioblastoma