GPR40 role in insulin secretion (Homo sapiens)

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1, 21, 21, 21, 21, 21, 21, 21, 21, 2Factin Remodelingenabling insulin exocytosisInsulin containing vesicle Insulin Exocytosis F-actin filamentsPancreatic Beta cellEndoplasmic ReticulumPLCB2DAGPLCD3PLCD1PLCE1IP3Rinositol-3-phosphatePLCB1PLCZ1PLCG2PLCB3PLCL1Unknown target genesPKD1PLCG1GPR40Ca2+PLCH1GNA11


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Poitout V, Lin DC; ''Modulating GPR40: therapeutic promise and potential in diabetes''; , 2013 PubMed Europe PMC Scholia
  2. Mancini AD, Poitout V; ''The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? Mancini AD1, Poitout V.''; , 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140057view07:26, 21 July 2025EgonwCalcium ion with unicode
138946view01:54, 8 May 2025EweitzModified title
138945view01:18, 8 May 2025EweitzModified description
138944view00:16, 8 May 2025EweitzOntology Term : 'type B pancreatic cell' added !
138943view00:06, 8 May 2025EweitzLabel group, refine group style
138942view00:02, 8 May 2025EweitzAlign nodes
138941view00:00, 8 May 2025EweitzTailor nodes, arrange graphics
138940view23:54, 7 May 2025EweitzStandardize case
138939view23:53, 7 May 2025EweitzCopyedit
138938view23:52, 7 May 2025EweitzTailor nodes, standardize case, refine cell type label
138937view23:49, 7 May 2025EweitzEconomize layout
138936view23:29, 7 May 2025EweitzIncrease font size
138935view23:29, 7 May 2025EweitzEconomize layout
117148view09:42, 18 May 2021EweitzModified title
107154view14:24, 17 September 2019MaintBotChEBI identifier normalization
96485view16:36, 15 March 2018Fehrhartfixed connection
94758view15:41, 5 October 2017Mkutmonfix unconnected lines
91307view18:43, 26 January 2017KhanspersModified title
91076view20:35, 30 December 2016AlexanderPicoOntology Term : 'insulin secretion pathway' added !
91075view20:34, 30 December 2016AlexanderPicoOntology Term : 'G protein mediated signaling pathway' added !
91074view20:29, 30 December 2016AlexanderPicoManually fixed literature reference
91064view12:24, 29 December 2016EgonwSmall fix in one of the IDs.
91057view22:56, 27 December 2016SiddiqaOntology Term : 'signaling pathway' added !
91056view22:54, 27 December 2016SiddiqaModified description
91055view22:45, 27 December 2016SiddiqaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Ca2+Metabolite29108 (ChEBI)
DAGMetabolite18035 (ChEBI)
GNA11GeneProductENSG00000088256 (Ensembl)
GPR40GeneProductENSG00000126266 (Ensembl)
IP3RGeneProductENSG00000096433 (Ensembl)
PKD1GeneProductENSG00000008710 (Ensembl)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCD1GeneProductENSG00000187091 (Ensembl)
PLCD3GeneProductENSG00000161714 (Ensembl)
PLCE1GeneProductENSG00000138193 (Ensembl)
PLCG1GeneProductEnsembl:ENSG00000124181 (Ensembl)
PLCG2GeneProductENSG00000197943 (Ensembl)
PLCH1GeneProductENSG00000114805 (Ensembl)
PLCL1GeneProductENSG00000115896 (Ensembl)
PLCZ1GeneProductENSG00000139151 (Ensembl)
Unknown target genesGeneProduct
inositol-3-phosphateMetabolite16595 (ChEBI)

Annotated Interactions

No annotated interactions

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