Nanomaterial-induced inflammasome activation (Homo sapiens)

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1, 2LysosomeInflammasomeNanomaterial-Associated Molecular Patterns ROS productionCaspase-1NADPH oxidase 1Caspase-1 (Fragment)ASC TLR4LPS coreIL1BTLR2Cathepsin Bpro-IL-1bIL1BPotassiumNFKB1NLRP3Potassium


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bhattacharya K, Andón FT, El-Sayed R, Fadeel B; ''Mechanisms of carbon nanotube-induced toxicity: focus on pulmonary inflammation.''; Adv Drug Deliv Rev, 2013 PubMed Europe PMC Scholia
  2. Farrera C, Fadeel B; ''It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system.''; Eur J Pharm Biopharm, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134328view12:51, 20 July 2024EweitzStandardize case
134281view05:21, 20 July 2024EgonwRemoved a template comment
124504view08:41, 3 November 2022JPM van RijnModified description
116457view10:02, 7 May 2021EweitzModified title
110231view14:27, 27 April 2020EgonwNot a mim-conversion
109788view01:37, 1 April 2020AlexanderPicoModified title
109787view01:35, 1 April 2020AlexanderPicoupdated xrefs and layout
106757view13:24, 17 September 2019MaintBotHMDB identifier normalization
94756view15:35, 5 October 2017Mkutmonfix unconnected lines
92318view08:51, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
92313view08:47, 20 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
91312view19:08, 26 January 2017KhanspersModified title
89364view06:25, 8 September 2016TorresandonModified description
89363view06:13, 8 September 2016TorresandonPAMPs
89362view06:07, 8 September 2016TorresandonUpdate TLR receptor and necessary stimuli for the activation of the pathway
89305view13:23, 31 August 2016EgonwOntology Term : 'regulatory pathway' added !
89304view13:23, 31 August 2016EgonwOntology Term : 'macrophage' added !
89303view13:22, 31 August 2016EgonwOntology Term : 'PW:0001018' removed !
89302view13:22, 31 August 2016EgonwOntology Term : 'innate immune response pathway' added !
89301view13:21, 31 August 2016EgonwOntology Term : 'immune system disease pathway' added !
89286view13:09, 30 August 2016TorresandonAdd references
89285view13:06, 30 August 2016TorresandonAdd references
89284view12:13, 30 August 2016TorresandonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASC
Caspase-1 (Fragment)ProteinH0YEC7 (Uniprot-TrEMBL)
Caspase-1ProteinB4DVD8 (Uniprot-TrEMBL)
Cathepsin BProteinE9PCB3 (Uniprot-TrEMBL)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1BProteinP01584 (Uniprot-TrEMBL)
LPS coreMetaboliteHMDB13471 (HMDB)
NADPH oxidase 1ProteinA6NGA6 (Uniprot-TrEMBL)
NFKB1GeneProductNFKB1 (HGNC)
NLRP3ProteinA0A024R5Q0 (Uniprot-TrEMBL)
PotassiumMetaboliteHMDB00586 (HMDB)
ROS productionMetaboliteCHEBI:26523 (ChEBI)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
pro-IL-1bProteinP01584 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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