let-7 inhibition of ES cell reprogramming (Homo sapiens)
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Description
Four transcription factors (OCT4, KLF4, SOX2, and c-MYC) reprogram adult cells into stem cells. MicroRNA let-7 is a barrier to reprogramming that inhibits LIN-41, a strong reprogramming factor that is expressed in pluripotent embryonic stem cells. LIN-41 inhibits the transcription factor EGR1, which promotes cell differentiation and is another barrier to reprogramming. (Description from Worringer et al)
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Ontology Terms
Saving...Bibliography
- Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S; ''The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.''; Cell Stem Cell, 2014 PubMed Europe PMC Scholia
History
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| EGR1 | GeneProduct | ENSG00000120738 (Ensembl)  | |
| KLF4 | GeneProduct | ENSG00000136826 (Ensembl) | |
| LIN-41 | GeneProduct | ENSG00000206557 (Ensembl) | |
| MIRLET7A1 | GeneProduct | ENSG00000199165 (Ensembl) | |
| MIRLET7A2 | GeneProduct | ENSG00000198975 (Ensembl) | |
| MIRLET7A3 | GeneProduct | ENSG00000198986 (Ensembl) | |
| MIRLET7C | GeneProduct | ENSG00000199030 (Ensembl) | |
| MIRLET7D | GeneProduct | ENSG00000199133 (Ensembl) | |
| MIRLET7E | GeneProduct | ENSG00000198972 (Ensembl) | |
| MIRLET7F1 | GeneProduct | ENSG00000199072 (Ensembl) | |
| MIRLET7F2 | GeneProduct | ENSG00000208012 (Ensembl) | |
| MIRLET7G | GeneProduct | ENSG00000199150 (Ensembl) | |
| MIRLET7I | GeneProduct | ENSG00000199179 (Ensembl) | |
| OCT4 | GeneProduct | 5460 (Entrez Gene) | |
| SOX2 | GeneProduct | ENSG00000181449 (Ensembl) | |
| c-MYC | GeneProduct | ENSG00000136997 (Ensembl) |
Annotated Interactions
No annotated interactions
