Cardiac hypertrophic response (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	142488	view	12:59, 5 March 2026	Eweitz	Increase font size
	139973	view	04:49, 14 July 2025	Egonw	Calcium ion with unicode
	137746	view	17:55, 7 March 2025	Khanspers	Modified description
	117670	view	11:58, 22 May 2021	Eweitz	Modified title
	106724	view	13:16, 17 September 2019	MaintBot	HMDB identifier normalization
	106349	view	21:36, 21 August 2019	Khanspers	Modified description
	105550	view	06:11, 9 August 2019	Khanspers	Modified description
	97631	view	10:45, 31 May 2018	AMTan	Ontology Term : 'hypertrophic cardiomyopathy' added !
	97630	view	10:45, 31 May 2018	AMTan	Ontology Term : 'cardiac muscle cell' added !
	96685	view	23:58, 26 March 2018	AlexanderPico	paths
	96684	view	23:56, 26 March 2018	AlexanderPico	updated interaction paths
	96683	view	23:54, 26 March 2018	AlexanderPico	updated font size and interaction paths
	85087	view	23:02, 12 April 2016	Egonw	Quick edit to datanode annotation or property
	78544	view	10:30, 7 January 2015	MaintBot	added missing graphIds
	76316	view	19:11, 1 July 2014	Cgrove	Changed typo of "PCL" for "Phospholipase C" to "PLC"
	74825	view	09:37, 30 April 2014	Mkutmon	Modified description
	74824	view	09:35, 30 April 2014	Mkutmon	Ontology Term : 'hypertrophic cardiomyopathy pathway' added !
	74823	view	09:34, 30 April 2014	Mkutmon	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
AKT1	GeneProduct	207 (Entrez Gene)
AKT2	GeneProduct	208 (Entrez Gene)
ANP	Protein	4878 (Entrez Gene)
Ang-II	Metabolite	HMDB01035 (HMDB)
BNP	Protein
CDK 7	GeneProduct	1022 (Entrez Gene)
CDK 9	GeneProduct	1025 (Entrez Gene)
Ca2+	Metabolite	HMDB00464 (HMDB)
CaMK	GeneProduct	817 (Entrez Gene)
Calcineurin	GeneProduct	5530 (Entrez Gene)
Calmodulin	GeneProduct	801 (Entrez Gene)
Catecholamines	Metabolite
DAG	Metabolite	HMDB07009 (HMDB)
EGF	Protein	1950 (Entrez Gene)
ERK1	GeneProduct	5595 (Entrez Gene)
ERK2	GeneProduct	5594 (Entrez Gene)
ERK5	GeneProduct	5598 (Entrez Gene)
Endo-1	Protein
FGF	Protein	2247 (Entrez Gene)
FGFR	Protein	2263 (Entrez Gene)
GC-A	GeneProduct	2978 (Entrez Gene)
GPCR	Protein
GSK3-beta	GeneProduct	2932 (Entrez Gene)
HDAC 4	GeneProduct	9759 (Entrez Gene)
HDAC 5	GeneProduct	10014 (Entrez Gene)
HDAC 7	GeneProduct	51564 (Entrez Gene)
HDAC 9	GeneProduct	9734 (Entrez Gene)
I-kappa-B	GeneProduct	9641 (Entrez Gene)
IGF-I	Protein	3479 (Entrez Gene)
IKK-alpha	GeneProduct	1147 (Entrez Gene)
IKK-beta	GeneProduct	3551 (Entrez Gene)
IKK-gamma	GeneProduct	8517 (Entrez Gene)
Ins(1,4,5)P3	Metabolite	HMDB01498 (HMDB)
JNK	GeneProduct	5599 (Entrez Gene)
MAPKKK	GeneProduct	4214 (Entrez Gene)
MAPKKKK	GeneProduct	11184 (Entrez Gene)
MEF2	GeneProduct	4205 (Entrez Gene)
MEK1	GeneProduct	5604 (Entrez Gene)
MEK2	GeneProduct	5605 (Entrez Gene)
MEK3	GeneProduct	5606 (Entrez Gene)
MEK4	GeneProduct	6416 (Entrez Gene)
MEK5	GeneProduct	5607 (Entrez Gene)
MEK6	GeneProduct	5608 (Entrez Gene)
MEK7	GeneProduct	5609 (Entrez Gene)
NF-kappa-B	GeneProduct	4790 (Entrez Gene)
NFAT	GeneProduct	4773 (Entrez Gene)
NIK	GeneProduct	9020 (Entrez Gene)
Neuregulin	Protein	3084 (Entrez Gene)
PCL	GeneProduct
PDK1	GeneProduct	5170 (Entrez Gene)
PKC	GeneProduct	5578 (Entrez Gene)
PKD	GeneProduct	5587 (Entrez Gene)
PKG-I	GeneProduct	5592 (Entrez Gene)
PLA2	GeneProduct	5320 (Entrez Gene)
Pol II	GeneProduct
RAC1	GeneProduct	5879 (Entrez Gene)
RAF1	GeneProduct	5894 (Entrez Gene)
RAS	GeneProduct
ROH	GeneProduct
RTKs	Protein
TAK1	GeneProduct	6885 (Entrez Gene)
TGF-beta	Protein	7040 (Entrez Gene)
TGFR/Activin	Protein	7046 (Entrez Gene)
TNF-alpha	Protein	7124 (Entrez Gene)
TNFR	Protein	7132 (Entrez Gene)
cGMP	Metabolite	HMDB01314 (HMDB)
mTOR	GeneProduct	2475 (Entrez Gene)
p38	GeneProduct	1432 (Entrez Gene)

Annotated Interactions

No annotated interactions