PDGF pathway (Homo sapiens)

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PCa2+PLCG1MAP3K1(MEKK1)H-Ras-1(Ras)STAT3SHC1SOS1SH-PTP2(PTN11)PDGFACachannelMAP2K4(JNKK1)RAF1MAPK8(JNK1)RASA1(GAP)IP3NFkBPLA2G4A(cPLA2)Cell proliferationAP-1(c-Jun)COX2PDGFBSTAT1PDGFRBProstaglandin I2(PGI2)PIP2[4',5']Cyclic AMP(cAMP)GRB2MP2K1(MEK 1)PDGFANFkBSTAT1STAT3STAT3STAT1PPPPSTAT3STAT1PPPJAK1P[Ca2+]iP


Description

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Bibliography

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  1. Hannink M, Donoghue DJ; ''Structure and function of platelet-derived growth factor (PDGF) and related proteins.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  2. Smith CL, Tallquist MD; ''PDGF function in diverse neural crest cell populations.''; Cell Adh Migr, 2010 PubMed Europe PMC Scholia
  3. Heldin CH; ''Autocrine PDGF stimulation in malignancies.''; Ups J Med Sci, 2012 PubMed Europe PMC Scholia
  4. Claesson-Welsh L, Heldin CH; ''Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.''; Acta Oncol, 1989 PubMed Europe PMC Scholia
  5. Kawahara RS, Deng ZW, Deuel TF; ''PDGF and the small inducible gene (SIG) family: roles in the inflammatory response.''; Adv Exp Med Biol, 1991 PubMed Europe PMC Scholia
  6. Heldin CH, Hammacher A, Nistأ©r M, Westermark B; ''Structural and functional aspects of platelet-derived growth factor.''; Br J Cancer, 1988 PubMed Europe PMC Scholia
  7. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S; ''PDGF: the nuts and bolts of signalling toolbox.''; Tumour Biol, 2011 PubMed Europe PMC Scholia
  8. Antoniades HN; ''PDGF: a multifunctional growth factor.''; Baillieres Clin Endocrinol Metab, 1991 PubMed Europe PMC Scholia
  9. Heldin CH, Westermark B; ''Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors.''; Br Med Bull, 1989 PubMed Europe PMC Scholia
  10. Andrae J, Gallini R, Betsholtz C; ''Role of platelet-derived growth factors in physiology and medicine.''; Genes Dev, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140649view06:17, 28 September 2025EgonwRemoved unfinished part of the sentence
139970view04:45, 14 July 2025EgonwMore unicode
137646view11:42, 6 March 2025EweitzUse gene symbols
137645view11:36, 6 March 2025EweitzEconomize layout
137644view11:29, 6 March 2025EweitzStandardize case
137643view02:21, 6 March 2025EweitzTailor custom node dimensions
137642view02:17, 6 March 2025EweitzTailor node dimensions
137641view02:07, 6 March 2025EweitzEconomize layout
137640view02:05, 6 March 2025EweitzEconomize layout
137639view01:47, 6 March 2025EweitzEconomize layout
137638view01:40, 6 March 2025EweitzEconomize layout
137637view01:36, 6 March 2025EweitzEconomize layout
137636view01:17, 6 March 2025EweitzUse gene symbols
137635view00:57, 6 March 2025EweitzEconomize layout
137578view12:57, 4 March 2025EweitzIncrease font size
137577view12:54, 4 March 2025EweitzUse simpler, straighter lines for interactions
137576view12:49, 4 March 2025EweitzUse simpler, straighter lines for interactions
137107view22:57, 27 February 2025KhanspersModified description
123068view04:20, 23 June 2022EgonwMade a pathway clickable
121697view03:35, 26 February 2022EweitzUse official gene symbol
117815view14:48, 22 May 2021EweitzModified title
107132view14:21, 17 September 2019MaintBotChEBI identifier normalization
106717view13:15, 17 September 2019MaintBotHMDB identifier normalization
106552view00:13, 6 September 2019KhanspersModified description
105476view05:22, 8 August 2019KhanspersModified description
103637view23:03, 22 March 2019AlexanderPicofixed xref datasource
101933view12:40, 18 November 2018EgonwRemoved whitespace in PubMed identifiers.
96312view09:02, 8 March 2018Mkutmonremove outdated pathway attributes
96257view16:14, 2 March 2018EgonwOntology Term : 'platelet-derived growth factor signaling pathway' added !
95977view15:52, 11 February 2018EgonwThese interactions are not mim-conversions.
82681view13:07, 22 October 2015EgonwReplace CAS numbers of CaCl2 with ChEBI identifiers for the actual metabolites.
80006view12:18, 30 April 2015Zariannotated and updated Id for ERK1/2 (MAPK3/MAPK1), H-Ras-1 (Ras) , MAP2K4 (JNKK1)
78551view10:30, 7 January 2015MaintBotadded missing graphIds
76331view08:11, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
72247view21:52, 29 October 2013Khanspersremoved GeneOntology xrefs from data nodes
72152view11:00, 25 October 2013EgonwAdded a ChEBI ID for 'phospholipid'.
72031view13:04, 24 October 2013Mkutmonfixed unconnected lines
71715view20:08, 17 October 2013MaintBotUpdated data sources
70400view23:27, 28 July 2013AmanzoWork in progress
70399view23:24, 28 July 2013AmanzoWork in progress
70398view23:17, 28 July 2013AmanzoPeriodical save, work in progress
70397view22:47, 28 July 2013AmanzoPeriodical save, work in progress
70396view22:37, 28 July 2013AmanzoPeriodical save, work in progress
70395view22:27, 28 July 2013AmanzoPeriodical save, work in progress
70394view22:17, 28 July 2013AmanzoPeriodical save, work in progress
70393view22:07, 28 July 2013AmanzoPeriodical save, work in progress
70294view17:24, 16 July 2013AmanzoReferences added
70293view17:18, 16 July 2013AmanzoPeriodical save, work in progress
70292view17:05, 16 July 2013AmanzoOntology Term : 'cancer' added !
70291view17:05, 16 July 2013AmanzoOntology Term : 'Jak-Stat signaling pathway' added !

External references

DataNodes

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NameTypeDatabase referenceComment

Ca

c h a n n e

l		ProteinGO:0034704 (GeneOntology)
AP-1 (c-Jun)GeneProductP05412 (Uniprot/TrEMBL)
COX2ProteinP00403 (Uniprot/TrEMBL)
Ca2+Metabolite10043-52-4 (CAS)
Cell proliferationPathwayGO:0042127 (GeneOntology)
Cyclic AMP (cAMP)MetaboliteHMDB00058 (HMDB)
GRB2ProteinP62993 (Uniprot/TrEMBL)
H-Ras-1 (Ras)GeneProduct
IP3Metabolite16595 (ChEBI)
JAK1ProteinP23458 (Uniprot/TrEMBL)
MAP2K4 (JNKK1)GeneProduct
MAP3K1 (MEKK1)GeneProductQ13233 (Uniprot/TrEMBL)
MAPK8 (JNK1)GeneProductP45983 (Uniprot/TrEMBL)
MP2K1 (MEK 1)GeneProductQ02750 (Uniprot/TrEMBL)
NFkBGeneProduct4790 (KEGG Genes)
P

D G F

A		GeneProduct5154 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PLA2G4A (cPLA2)GeneProductENSG00000116711 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
Prostaglandin I2 (PGI2)MetaboliteHMDB01335 (HMDB)
RAF1ProteinP04049 (Uniprot/TrEMBL)
RASA1(GAP)GeneProductENSG00000145715 (Ensembl Human)
SH-PTP2 (PTN11)GeneProductQ06124 (Uniprot/TrEMBL)
SHC1ProteinP29353 (Uniprot/TrEMBL)
SOS1ProteinQ07889 (Uniprot/TrEMBL)
STAT1ProteinP42224 (Uniprot/TrEMBL)
STAT3ProteinP40763 (Uniprot/TrEMBL)
[Ca2+]iMetabolite10043-52-4 (CAS)

Annotated Interactions

No annotated interactions

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