miR-1 in cardiac development (Mus musculus)
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Description
This pathway is an adaptation from figure 2.a in Stefani et al. (2008). miR-1 regulates cardiac morphogenesis by optimizing the level of the HAND2 transcription factor. Electric conduction is abnormal in mice that lack miR-1 as a consequence of de-inhibition of IRX5, a homeodomain-containing transcription factor that represses the expression of the KCND2 potassium channel.
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Ontology Terms
Saving...Bibliography
- Stefani G, Slack FJ; ''Small non-coding RNAs in animal development.''; Nat Rev Mol Cell Biol, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Hand2 | GeneProduct | 15111 (Entrez Gene)  | |
| Irx5 | GeneProduct | 54352 (Entrez Gene) | |
| Kcnd2 | GeneProduct | 16508 (Entrez Gene) | |
| mmu-mir-1-1 | Rna | MI0000139 (miRBase) | |
| mmu-mir-1-2 | Rna | MI0000652 (miRBase) |
Annotated Interactions
No annotated interactions
