Androgen receptor network in prostate cancer (Homo sapiens)

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Apoptotic PathwaysFOXA1MYCFKBP5ARAR* 3-beta-OH-delta-steroid DH & Steroid isomerase =*** Estradiol-17-beta DH = DHB****HSD3B2CYP17A1HSD3B1HSD3B1HSD17B717-alpha-OH-ProgesteroneDihydrotestosteroneHSD3B1HSD3B1AndrostenedioneHSD3B1Hydroxyprogesterone aldolaseHSD3B1ProgesteroneEstradiolHSD3B2TestosteroneHSD3B1EstroneHSD3B1HSD3B1AndrostenediolHSD3B1F13BGlucocortocoid SynthesisHSD3B1HSD3B1HSD17B4HSD3B1Hydroxyprogesterone aldolaseHSD3B1HSD3B1Hydroxyprogesterone aldolaseSteroid-19-HydroxylaseHSD3B2PregnenoloneCYP17A1HSD3B1HSD3B2HSD3B1HSD17B2HSD3B1HSD3B1HSD17B317-alpha-OH-PregnenoloneHSD17B1HSD3B1CholesterolHSD3B1Mineralocortocoid SynthesisSteroid-19-HydroxylaseBASC ComlexRAD50_HUMANOCT1MSH6_HUMANp14CDC2_HUMANp38ATF1Swi/SNFASK1BRCA1_HUMANCASP8_HUMANPLK1ATR_HUMANBARD1_HUMANCASP9_HUMANCDC25BPUMARB_HUMANSMAD3_HUMANNOXA1_HUMANBLM_HUMANQ8NBS1_HUMANCDK4_HUMANMRE11_HUMANSTAT1_HUMANCDC25ABCL2_HUMANAKT1_HUMANCASP3_HUMANBACH1PTEN_HUMANP53_HUMANCHK2_HUMANp15MYCJAK1_HUMANp27MSH2_HUMANBAX_HUMANp13KDNA-PKCHK1_HUMANCctlpBRCA1_HUMANMMP1_HUMANCDK2_HUMANBAD_HUMANATM_HUMANSMAD2_HUMANE2F1_HUMANMDM2_HUMANp21TMPRSS2KLK3KLK2NDRG1ABCC4TMPRSS2TMPRSS2


Description

No description

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Ontology Terms

 

Bibliography

  1. Liu LZ, Li C, Chen Q, Jing Y, Carpenter R, Jiang Y, Kung HF, Lai L, Jiang BH; ''MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression.''; PLoS One, 2011 PubMed Europe PMC Scholia
  2. Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, Demichelis F, Helgeson BE, Laxman B, Morris DS, Cao Q, Cao X, Andrén O, Fall K, Johnson L, Wei JT, Shah RB, Al-Ahmadie H, Eastham JA, Eggener SE, Fine SW, Hotakainen K, Stenman UH, Tsodikov A, Gerald WL, Lilja H, Reuter VE, Kantoff PW, Scardino PT, Rubin MA, Bjartell AS, Chinnaiyan AM; ''The role of SPINK1 in ETS rearrangement-negative prostate cancers.''; Cancer Cell, 2008 PubMed Europe PMC Scholia
  3. Schramedei K, Mörbt N, Pfeifer G, Läuter J, Rosolowski M, Tomm JM, von Bergen M, Horn F, Brocke-Heidrich K; ''MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4.''; Oncogene, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140881view00:52, 30 October 2025EweitzClear deprecataed metadata rendering
138743view00:53, 1 May 2025EweitzFix PathVisio / Kaavio graphical discrepancy
138742view00:43, 1 May 2025EweitzRefine interaction position, use gene symbol
138741view00:39, 1 May 2025EweitzFix PathVisio / Kaavio graphical discrepancy
138740view00:35, 1 May 2025EweitzEconomize layout
138739view00:31, 1 May 2025EweitzUpgrade SWI / SNF from group to complex
138738view00:29, 1 May 2025EweitzEconomize layout
138737view00:27, 1 May 2025EweitzEconomize layout
138736view00:07, 1 May 2025EweitzRefine interaction position
138735view00:05, 1 May 2025EweitzEconomize layout
138725view12:53, 30 April 2025EweitzUse gene symbols
138724view12:45, 30 April 2025EweitzFix typo, refine interaction positions
138723view12:43, 30 April 2025EweitzEconomize layout
138722view12:37, 30 April 2025EweitzRefine cell compartment layering
138721view12:37, 30 April 2025EweitzEconomize layout
138720view12:33, 30 April 2025EweitzRefine interaction positions
138719view12:30, 30 April 2025EweitzEconomize layout
138718view12:27, 30 April 2025EweitzEconomize layout
138717view12:23, 30 April 2025EweitzEconomize layout
138716view12:19, 30 April 2025EweitzEconomize layout
138715view11:58, 30 April 2025EweitzRefine interaction positions
138714view11:56, 30 April 2025EweitzEconomize layout
138713view11:55, 30 April 2025EweitzEconomize layout, use gene symbols
137779view05:52, 8 March 2025EgonwModified description
134233view11:42, 17 July 2024EweitzDisentangle interaction, avoid label-interaction occlusion
134232view11:39, 17 July 2024EweitzIncrease font size on all nodes, for readability
134231view11:29, 17 July 2024EweitzEconomize layout
134230view11:21, 17 July 2024EweitzEconomize layout
134229view10:59, 17 July 2024EweitzImprove contrast for readability, standardize case
134228view10:57, 17 July 2024EweitzEconomize layout
134227view10:43, 17 July 2024EweitzEconomize layout
134226view10:30, 17 July 2024EweitzEconomize layout
134225view10:25, 17 July 2024EweitzEconomize layout
134224view10:20, 17 July 2024EweitzEconomize layout
134223view10:13, 17 July 2024EweitzFix modeling, refine interaction connection point
134222view10:08, 17 July 2024EweitzEconomize organelle shape
134216view08:00, 17 July 2024EgonwRemoved template comments
127838view04:43, 23 December 2023EweitzMove two genes back into circle, refine case
127837view04:38, 23 December 2023EweitzFurther economize layout
127836view03:39, 23 December 2023EweitzFurther economize layout
127834view03:13, 23 December 2023EweitzEconomize layout, fix typo
125525view17:04, 25 February 2023EgonwUpdated a data source
123536view14:39, 2 August 2022EgonwMade two pathways clickable
121719view15:54, 26 February 2022EweitzRefine case, use gene symbols
116551view12:49, 7 May 2021EweitzModified title
115243view17:15, 7 February 2021EgonwReplaced links to a deleted pathway with an equivalent existing pathway
108261view14:47, 3 December 2019L DupuisConnected unconnected line
108107view10:17, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106708view13:14, 17 September 2019MaintBotHMDB identifier normalization
98360view06:13, 24 August 2018EgonwUpdated the MIR21 identifier.

External references

DataNodes

View all...
NameTypeDatabase referenceComment
17-alpha-OH-PregnenoloneMetaboliteHMDB00363 (HMDB)
17-alpha-OH-ProgesteroneMetaboliteHMDB00374 (HMDB)
ABCC4GeneProduct10257 (Entrez Gene)
AKT1_HUMANProteinP31749 (Uniprot/TrEMBL)
ARProtein367 (Entrez Gene) AR
ASK1Protein
ATF1Protein
ATM_HUMANProteinQ13315 (Uniprot/TrEMBL)
ATR_HUMANProteinQ13535 (Uniprot/TrEMBL)
AndrostenediolMetaboliteHMDB05849 (HMDB)
AndrostenedioneMetabolite63-05-8 (CAS)
BACH1Protein
BAD_HUMANProteinQ92934 (Uniprot/TrEMBL)
BARD1_HUMANProteinQ99728 (Uniprot/TrEMBL)
BAX_HUMANProteinQ07812 (Uniprot/TrEMBL)
BCL2_HUMANProteinP10415 (Uniprot/TrEMBL)
BLM_HUMANProteinP54132 (Uniprot/TrEMBL)
BRCA1_HUMANProteinP38398 (Uniprot/TrEMBL)
CASP3_HUMANProteinP42574 (Uniprot/TrEMBL)
CASP8_HUMANProteinQ14790 (Uniprot/TrEMBL)
CASP9_HUMANProteinP55211 (Uniprot/TrEMBL)
CDC25AGeneProductENSG00000164045 (Ensembl Human)
CDC25BGeneProductENSG00000101224 (Ensembl Human)
CDC2_HUMANProteinP06493 (Uniprot/TrEMBL) Oncogene
CDK2_HUMANProteinP24941 (Uniprot/TrEMBL)
CDK4_HUMANProteinP11802 (Uniprot/TrEMBL)
CHK1_HUMANProteinO14757 (Uniprot/TrEMBL)
CHK2_HUMANProteinO96017 (Uniprot/TrEMBL) Phosphrylated
CYP17A1GeneProduct1586 (Entrez Gene)
CctlpProtein
CholesterolMetabolite57-88-5 (CAS)
DNA-PKMetabolite
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
E2F1_HUMANProteinQ01094 (Uniprot/TrEMBL)
EstradiolMetabolite57-91-0 (CAS)
EstroneMetabolite53-16-7 (CAS)
F13BGeneProduct2165 (Entrez Gene)
FKBP5GeneProduct2289 (Entrez Gene)
FOXA1GeneProduct3169 (Entrez Gene) DNA licensing factor for AR. Frequently occupies regions in enhancers with DNA recognition elements close to AR ARE
Glucocortocoid SynthesisPathwayWP237 (WikiPathways)
HSD17B1GeneProduct3292 (Entrez Gene)
HSD17B2GeneProduct3294 (Entrez Gene)
HSD17B3GeneProduct3293 (Entrez Gene)
HSD17B4GeneProduct3295 (Entrez Gene)
HSD17B7GeneProduct51478 (Entrez Gene)
HSD3B1GeneProduct3283 (Entrez Gene)
HSD3B2GeneProduct3284 (Entrez Gene)
Hydroxyprogesterone aldolaseGeneProduct4.1.2.30 (EC Number)
Hydroxyprogesterone aldolaseMetabolite53-43-0 (CAS)
JAK1_HUMANProteinP23458 (Uniprot/TrEMBL)
KLK2GeneProduct3817 (Entrez Gene)
KLK3GeneProduct354 (Entrez Gene)
MDM2_HUMANProteinQ00987 (Uniprot/TrEMBL) Oncogene
MMP1_HUMANProteinP03956 (Uniprot/TrEMBL)
MRE11_HUMANProteinP49959 (Uniprot/TrEMBL)
MSH2_HUMANProteinP43246 (Uniprot/TrEMBL)
MSH6_HUMANProteinP52701 (Uniprot/TrEMBL)
MYCProtein
MYCGeneProductENSG00000136997 (Ensembl Human)
Mineralocortocoid SynthesisPathwayWP237 (WikiPathways)
NDRG1GeneProduct10397 (Entrez Gene)
NOXA1_HUMANProteinQ86UR1 (Uniprot/TrEMBL)
OCT1Protein
P53_HUMANProteinP04637 (Uniprot/TrEMBL)
PLK1GeneProductENSG00000166851 (Ensembl Human)
PTEN_HUMANProteinP60484 (Uniprot/TrEMBL)
PUMAProtein
PregnenoloneMetabolite145-13-1 (CAS)
ProgesteroneMetabolite57-83-0 (CAS)
Q8NBS1_HUMANProteinQ8NBS1 (Uniprot/TrEMBL)
RAD50_HUMANProteinQ92878 (Uniprot/TrEMBL)
RB_HUMANProteinP06400 (Uniprot/TrEMBL)
SMAD2_HUMANProteinQ15796 (Uniprot/TrEMBL) Tumor supressor
SMAD3_HUMANProteinP84022 (Uniprot/TrEMBL)
STAT1_HUMANProteinP42224 (Uniprot/TrEMBL)
Steroid-19-HydroxylaseGeneProductENSG00000120054 (Ensembl Human)
Swi/SNFProtein
TMPRSS2GeneProduct7113 (HGNC)
TestosteroneMetabolite58-22-0 (CAS)
p13KProtein
p14Protein
p15Protein
p21Protein
p27Protein
p38Protein

Annotated Interactions

No annotated interactions

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