Endothelin pathways (Homo sapiens)

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Sensory motor nerveVasocontrictionIP1Arachidonic acidK+RAMP1K+ channelACPKASERCAsGCCa2+ channelcAMPCitrullineK+NOATPNPYL-ArginineCOX2EDHFPGI2a adrenergic receptorY1GTPeNOScGMPCRLRCa2+ channelCGRPEndothelin 1ECEIP3CapPKCGaQMLCBig ET1MEKEDNRAMLCKDAGERK1/2EDNRBFurin-like proteaseRAFPLCbIP3RPre-pro ET1CADCa2+CaMPIP2Pre-pro ET1Endothelin 1GbQGgQCa2+PMCACa2+EDNRBGaQGbQGgQPLCbPIP2IP3DAGCa2+Ca2+Ca2+ channelIP3RNOPGI2PKCCa2+K+GaSGbSGgSGaQGbQGgQb adrenergic receptorGaSGbSGgSSympathic nerveEndothelial cellSmooth muscle cellK+CGRPCGRPGaSGbSGgSK+K+NPYNPYGaIGbIGgINONOCa2+Cellular growth and survival


Description

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.

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Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
140176view07:16, 4 August 2025EgonwMore unicode
139947view05:01, 13 July 2025EgonwCalcium ion with unicode
137718view11:54, 7 March 2025EgonwModified description
134211view19:22, 16 July 2024EgonwRemoved template comments
117710view12:27, 22 May 2021EweitzModified title
108353view09:28, 11 December 2019L DupuisConverted interaction lines in vasoconstriction to graphical lines
106403view21:33, 28 August 2019KhanspersModified description
106134view12:03, 16 August 2019MaintBotHMDB identifier normalization
105584view04:42, 10 August 2019KhanspersModified description
94181view13:41, 25 August 2017Mkutmonadded missing metabolite identifiers
74852view08:47, 1 May 2014SabinedaemenSpecify description
71380view18:39, 17 October 2013MaintBotAutomated update of data sources
69912view19:37, 11 July 2013AlexanderPicoModified title
67194view10:19, 26 June 2013Christine ChichesterOntology Term : 'endothelin signaling pathway' added !
64830view21:33, 3 June 2013MaintBotModified title
63181view20:43, 8 May 2013MaintBotUpdating gpml version
59179view18:44, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57671view20:17, 31 January 2013KhanspersModified categories
56443view21:38, 7 January 2013EgonwAdded missing HMDB data source values.
48538view07:48, 3 June 2012MireilleSthijnsPeriodical save, work in progress
48535view10:31, 2 June 2012MireilleSthijnsPeriodical save, work in progress
48447view15:13, 24 May 2012Sabinedaemen
48446view15:10, 24 May 2012Sabinedaemen
48435view10:42, 24 May 2012Sabinedaemen
48434view10:39, 24 May 2012Sabinedaemen
48433view10:30, 24 May 2012SabinedaemenModified description
48432view10:20, 24 May 2012Sabinedaemen
48431view10:15, 24 May 2012Sabinedaemen
48430view10:13, 24 May 2012Sabinedaemen
48429view10:09, 24 May 2012SabinedaemenPeriodical save, work in progress
48428view10:01, 24 May 2012SabinedaemenSpecify description
48427view09:52, 24 May 2012SabinedaemenOntology Term : 'Ras superfamily mediated signaling pathway' added !
48426view09:51, 24 May 2012SabinedaemenOntology Term : 'calcium/calmodulin dependent signaling pathway' added !
48425view09:50, 24 May 2012SabinedaemenOntology Term : 'hypertension' added !
48424view09:49, 24 May 2012SabinedaemenOntology Term : 'smooth muscle cell' added !
48423view09:49, 24 May 2012SabinedaemenOntology Term : 'blood vessel endothelial cell' added !
48422view09:47, 24 May 2012SabinedaemenOntology Term : 'benign essential hypertension' added !
48421view09:44, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
48420view09:43, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphaq family' added !
48419view09:42, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphai family' added !
48418view09:40, 24 May 2012SabinedaemenSpecify description
48417view09:37, 24 May 2012MireilleSthijnsSpecify description
48416view09:34, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48415view09:29, 24 May 2012MireilleSthijnsSpecify description
48414view09:23, 24 May 2012MireilleSthijnsSpecify description
48413view09:14, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48412view09:04, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48411view08:59, 24 May 2012MireilleSthijnsSpecify description
48410view08:54, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48409view08:43, 24 May 2012MireilleSthijnsPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACGeneProductENSG00000143199 (Ensembl Human) adenylate cyclase
ATPMetaboliteHMDB01532 (HMDB)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Big ET1Protein
CADGeneProductENSG00000084774 (Ensembl Human)
  • Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
  • Type your comment here
CGRPGeneProductENSG00000110680 (Ensembl Human)
COX2GeneProduct4513 (Entrez Gene)
CRLRGeneProductENSG00000064989 (Ensembl Human)
Ca2+ channelProtein
Ca2+ channelGeneProduct
Ca2+MetaboliteHMDB00464 (HMDB)
CaMGeneProductENSG00000198668 (Ensembl Human)
CapGeneProductENSG00000130176 (Ensembl Human)
  • Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
  • Type your comment here
CitrullineMetaboliteHMDB00904 (HMDB)
DAGMetaboliteHMDB07008 (HMDB)
ECEGeneProductENSG00000117298 (Ensembl Human)
EDHFProtein
EDNRAGeneProductENSG00000151617 (Ensembl Human)
EDNRBGeneProductENSG00000136160 (Ensembl Human)
ERK1/2GeneProductENSG00000100030 (Ensembl Human)
Endothelin 1GeneProductENSG00000078401 (Ensembl Human)
Furin-like proteaseProtein
GTPMetaboliteHMDB01440 (HMDB)
GaIGeneProductENSG00000127955 (Ensembl Human)
GaQGeneProductENSG00000060558 (Ensembl Human)
GaSGeneProductENSG00000087460 (Ensembl Human)
GbIGeneProductENSG00000069966 (Ensembl Human)
GbQGeneProductENSG00000069966 (Ensembl Human)
GbSGeneProductENSG00000069966 (Ensembl Human)
GgIGeneProductENSG00000127588 (Ensembl Human)
GgQGeneProductENSG00000127588 (Ensembl Human)
GgSGeneProductENSG00000127588 (Ensembl Human)
IP1GeneProductENSG00000160013 (Ensembl Human) Prostaglandin I2 Receptor
IP3MetaboliteHMDB01059 (HMDB)
IP3RProtein
K+ channelProtein
K+MetaboliteHMDB00586 (HMDB)
L-ArginineMetaboliteHMDB00517 (HMDB)
MEKGeneProductENSG00000169032 (Ensembl Human)
MLCGeneProductENSG00000168530 (Ensembl Human) myosine light chain
MLCKGeneProductENSG00000065534 (Ensembl Human)
NOMetaboliteHMDB03378 (HMDB)
NPYGeneProductENSG00000122585 (Ensembl Human)
PGI2Metabolite
PIP2MetaboliteHMDB10032 (HMDB)
PKAGeneProductENSG00000178796 (Ensembl Human)
PKCGeneProductENSG00000154229 (Ensembl Human)
PLCbGeneProductENSG00000182621 (Ensembl Human)
PMCAProtein
Pre-pro ET1Protein
RAFGeneProductENSG00000132155 (Ensembl Human)
RAMP1GeneProductENSG00000132329 (Ensembl Human)
SERCAGeneProductENSG00000174437 (Ensembl Human)
Y1GeneProductENSG00000164128 (Ensembl Human)
a adrenergic receptorGeneProductENSG00000120907 (Ensembl Human)
b adrenergic receptorGeneProductENSG00000043591 (Ensembl Human)
cAMPMetaboliteHMDB00058
cGMPMetaboliteHMDB01314
eNOSGeneProductENSG00000164867 (Ensembl Human)
sGCGeneProductENSG00000123201 (Ensembl Human)

Annotated Interactions

No annotated interactions

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