Serotonin and anxiety (Mus musculus)

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3442ArcE-boxDissociationANXIETYpositive allosteric modulationCHRONICSTRESSde Novo synthesisNucleusMiscellaneous genespossibly involved465eEF2KPpp3caeEF2Fmr1ArcPrkcbDOCPlcd4Htr1aArcHtr2amGluR1PomcTrpv1CaMGabra1Ca2+FosHtr2cCrhTHDOCPlekCa2+eEF2KketanserinCa2+Adra1aeEF2-P31, 631mGluR141, 36eEF2-PArc4


Description

No description

Comments

 
Note that part of this pathway is based on results obtained from research done in rattus norvegicus.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Bramham CR, Worley PF, Moore MJ, Guzowski JF; ''The immediate early gene arc/arg3.1: regulation, mechanisms, and function.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  2. Reddy DS; ''Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions.''; Neuroscience, 2006 PubMed Europe PMC Scholia
  3. van der Starre PJ, Reneman RS; ''The alpha-adrenergic receptor blocking effect of ketanserin and the interaction between alpha-adrenergic and S2-serotonergic receptor blockade.''; J Cardiovasc Pharmacol, 1988 PubMed Europe PMC Scholia
  4. Shuttleworth TJ, Thompson JL, Mignen O; ''ARC channels: a novel pathway for receptor-activated calcium entry.''; Physiology (Bethesda), 2004 PubMed Europe PMC Scholia
  5. Jensen T, Edwards JG; ''Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons.''; Neurosci Lett, 2012 PubMed Europe PMC Scholia
  6. Benekareddy M, Vadodaria KC, Nair AR, Vaidya VA; ''Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress.''; Biol Psychiatry, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139946view05:00, 13 July 2025EgonwCalcium ion with unicode
101828view09:32, 12 November 2018EgonwReplaced old Uniprot data sources with the new ones.
95456view14:11, 15 December 2017DeSlChanged 2 additional IDs
95455view14:09, 15 December 2017DeSlchanged kegg ortholog to corresponding Uniprot ID
90850view19:59, 14 December 2016KhanspersModified description
89967view18:29, 6 October 2016Mkutmonfix unconnected lines
89802view11:32, 6 October 2016Mkutmonfixed special character in description
79764view20:02, 10 April 2015EgonwMissed a third annotation of a ortholog as a metabolite.
79760view07:00, 10 April 2015EgonweEF2 and eEF2-P are a gene products.
78416view10:25, 7 January 2015MaintBotadded missing graphIds
71728view20:17, 17 October 2013MaintBotUpdated data sources
70118view19:17, 12 July 2013MaintBotupdated to 2013 schema
68771view16:17, 7 July 2013EgonwFixed PubChem-compound data sources and identifiers.
67639view11:37, 26 June 2013DdiglesOntology Term : 'serotonin signaling pathway' added !
59053view20:55, 21 February 2013MaintBotUpdated Ensembl data source
58137view21:23, 8 February 2013MaintBotModified categories
58136view21:23, 8 February 2013MaintBotModified title
54703view13:29, 7 December 2012Andra
47355view16:44, 15 March 2012BurslemOntology Term : 'altered calcineurin signaling pathway' added !
47354view16:42, 15 March 2012BurslemOntology Term : 'anxiety disorder' added !
47352view16:40, 15 March 2012BurslemOntology Term : 'calcium/calmodulin dependent kinases pathway' added !
47351view16:40, 15 March 2012BurslemOntology Term : 'serotonergic neuron' added !
47350view16:35, 15 March 2012BurslemModified description
47331view14:47, 15 March 2012BurslemDatabase references
47328view14:39, 15 March 2012Burslemdatabase references
47327view14:38, 15 March 2012BurslemDatabase references
47325view14:34, 15 March 2012BurslemAnxiety
47320view14:25, 15 March 2012BurslemPeriodical save, work in progress
47315view14:13, 15 March 2012BurslemPeriodical save, work in progress
47311view14:02, 15 March 2012BurslemGABA receptor, THDOC
47308view13:53, 15 March 2012BurslemPeriodical save, work in progress
47304view13:46, 15 March 2012BurslemArc de novo synthesis
47303view13:43, 15 March 2012BurslemPeriodical save, work in progress
47299view13:37, 15 March 2012BurslemAddition of eEF2
47298view13:33, 15 March 2012BurslemPeriodical save, work in progress
47293view13:23, 15 March 2012BurslemPeriodical save, work in progress
47288view13:12, 15 March 2012BurslemPeriodical save, work in progress
47284view13:02, 15 March 2012BurslemPeriodical save, work in progress
47282view12:52, 15 March 2012BurslemPeriodical save, work in progress
47280view12:42, 15 March 2012BurslemPeriodical save, work in progress
47279view12:32, 15 March 2012BurslemPeriodical save, work in progress
47278view12:22, 15 March 2012BurslemPeriodical save, work in progress
47276view12:11, 15 March 2012BurslemPeriodical save, work in progress
47274view12:05, 15 March 2012BurslemLiterature addition
47272view12:01, 15 March 2012BurslemDecorative changes
47270view11:58, 15 March 2012BurslemPeriodical save, work in progress
47265view11:39, 15 March 2012HelixPeriodical save, work in progress
47258view11:29, 15 March 2012HelixPeriodical save, work in progress
47250view11:19, 15 March 2012HelixPeriodical save, work in progress
47243view11:09, 15 March 2012HelixNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Adra1aGeneProductENSMUSG00000045875 (Ensembl Mouse)
ArcGeneProductENSMUSG00000022602 (Ensembl Mouse)
Ca2+ MetaboliteCHEBI:29108 (ChEBI)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CaMGeneProductENSMUSG00000057897 (Ensembl Mouse)
CrhGeneProductENSMUSG00000049796 (Ensembl Mouse)
DOCMetaboliteCID 6166 (PubChem)
Fmr1GeneProductENSMUSG00000000838 (Ensembl Mouse)
FosGeneProductENSMUSG00000021250 (Ensembl Mouse)
Gabra1GeneProductENSMUSG00000010803GABA a receptor
Htr1aGeneProductENSMUSG00000021721 (Ensembl Mouse)
Htr2aGeneProductENSMUSG00000034997 (Ensembl Mouse)
Htr2cGeneProductENSMUSG00000041380 (Ensembl Mouse)
Plcd4GeneProductENSMUSG00000026173 (Ensembl Mouse)
PlekGeneProductENSMUSG00000020120 (Ensembl Mouse) pleckstrin
PomcGeneProductENSMUSG00000020660 (Ensembl Mouse)
Ppp3caGeneProductENSMUSG00000028161 (Ensembl Mouse) calcineurin
PrkcbGeneProductENSMUSG00000052889 (Ensembl Mouse) Protein kinase C
THDOCMetaboliteCID 91475 (PubChem)
Trpv1GeneProductENSMUSG00000005952 (Ensembl Mouse)
eEF2-PMetaboliteK03234 (Kegg Compound)
eEF2MetaboliteK03234 (Kegg Compound)
eEF2KGeneProductENSMUSG00000073853 (Ensembl Mouse) Phosphorylates eEF2
ketanserinCID 3822 (PubChem)
mGluR1GeneProductENSMUSG00000019828 ] (Ensembl Mouse) G-protein-coupled phosphatidylinositol-calcium second messenger system

Annotated Interactions

No annotated interactions
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