EGF/EGFR signaling pathway (Bos taurus)

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1PMAcetylationCYNUPMMAExtracellularMACYCYCYNUAutodephosphorylationCYNUCYMANUPlasma membraneNUMAPMPMENCYMethylationEnzyme complexDesumoylationEndoplasmic reticulumPMCYCYMATranslocationCYCYMolecular associationNUNUReceptorPalmitoylationCYCYPMNUPMCYPMActivationMAEndosomeCY(Protein-protein interaction)MAPMCYCYCYDAccession Number : NetPath 4; cellmap:4NUInhibitionProteins in a complex interactionCYCYMACYMADemethylationCYPMCytoplasmPMControlCYMAMAENMolecule in the pathwaySumoylationNUGlycosylationMAPMNUMAAutophosphorylationNUPMPMPMMADECMALigandNUMAPMGOMitochondrionMTUbiquitinationNUCYProteolytic cleavageCYCYDephosphorylationCYPMNUMACYNucleusENDeubiquitinationERNUPMMACYMACYDCYDeacetylationRecruitmentPMMACYNUCYNUPMPMPhosphorylationNUMANUGene SymbolReaction through unknown mechanisms/moleculesCYCYGolgi apparatusPMSIN3AMAPK8EGFRPTPN6PLEC1PIK3CDKRT17NDUFA13CREB1PEBP1RPS6KA3GAB1AP2A1EPPK1STAT5BPTPN6SHC1JAK1PRKD1CAMK2AEGFRCDC42STAT1MAP3K14CEACAM1EGFRLOC506618PLD2PRKCAARF4SPRY2SH2D3CARF4APPL1APPL1STAT2EGFMAP2K1PLCG2PLCG1CSKASAP1GRB7HIST3H3RPS6KA2STAT5APIK3CBMAPK1STAT3GIT1PIK3CARFXANKPTPN12ABI1MAP3K2LOC100138040PRKCBGAB2SHOC2EEF1A1WASLSOCS1SMAD3ERRFI1VAV2CASP9MTA2JUNDSMAD2NRASPTPRRPTK6REPS2SH2D3CMAP2K3PAK1PRKCGRBBP7MAP3K2STAT3RASA1PLCG2EPS15TGIF1VAV1SHC1PLD1ELF3MAPK7HDAC1MAP2K1SPRY2SNRPD2SNCAKRASMAP2K7PLSCR1ARAFSOCS3PTPN5RGS16SH3GL3STAT5AMAP3K1ELK4RPS6KA3MAPK14EGFRSP1PIK3R1PITPNACEBPBZNF259EGFSH3GL2APPL1MAP2K2PTK2BATF1CEBPADUSP1SH3KBP1STAT1RAF1YWHABSMAD2HRASPRKAR1AGAB1EGFSTAT3SOS1CRKMAP2K5REPS1PLD1RALBSMAD3RPS6KA5ARF4EPS15L1Grb10ITCHJAK2MAP3K3CAV2ELK1DUSP1PLCG1MAPK1WNK1RAC1HAT1KRT7TNIP1MAPK3STAT1MCF2KRT18HIP1PRKCIEPS15CRKLNCK1GRB2RALBP1MYCKRT8VAV3ZNF259DOK2USP6NLPRKCACAV1STAT2STXBP1RAB5ACTNND1PTPN11AKT1GRB14ELF3RIPK1PIK3R2SH3BGRLPXNSTXBP1INPPL1PKN2SRCCBLFOSTNK2RALGDSEEF1A1EPS8DIP13BJUNGJA1SH3GL2PIK3CGPRKCZKLF11BCAR1HTTEPN1LOC506618RAF1CBLBDNM1BCAR1MAP3K4RPS6KA1PIK3R3LOC537396DIP13BNCK2CBLC


Description

No description

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 88% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137196view23:25, 28 February 2025KhanspersModified description
119000view09:34, 8 June 2021FinterlyRemoved empty Comment
117501view11:04, 21 May 2021EweitzModified title
115936view08:10, 21 March 2021EgonwCopied the NetPath paper into the literature list
115935view08:09, 21 March 2021EgonwModified description
80732view15:23, 30 June 2015Mkutmonhomology conversion
67181view10:17, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63391view00:04, 10 May 2013MaintBotUpdated to 2013 gpml schema
40564view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
35721view23:29, 12 February 2010AlexanderPico
35435view11:32, 12 February 2010MichielAdded ref
33802view00:17, 9 December 2009MaintBotAutomatic update of empty xrefs
30547view21:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABI1GeneProduct540815 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
AP2A1GeneProduct
APPL1GeneProduct517850 (Entrez Gene)
ARAFGeneProduct540421 (Entrez Gene)
ARF4GeneProduct518601 (Entrez Gene)
ASAP1GeneProduct327705 (Entrez Gene)
ATF1GeneProduct506967 (Entrez Gene)
BCAR1GeneProduct527550 (Entrez Gene)
CAMK2AGeneProduct530719 (Entrez Gene)
CASP9GeneProduct100140945 (Entrez Gene)
CAV1GeneProduct281040 (Entrez Gene)
CAV2GeneProduct493642 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CBLBGeneProduct525906 (Entrez Gene)
CBLCGeneProduct615866 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CEACAM1GeneProduct
CEBPAGeneProduct281677 (Entrez Gene)
CEBPBGeneProduct338319 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
CSKGeneProduct509246 (Entrez Gene)
CTNND1GeneProduct515187 (Entrez Gene)
DIP13BGeneProduct
DNM1GeneProduct508794 (Entrez Gene)
DOK2GeneProduct514616 (Entrez Gene)
DUSP1GeneProduct539175 (Entrez Gene)
EEF1A1GeneProduct282220 (Entrez Gene)
EGFGeneProduct786061 (Entrez Gene)
EGFRGeneProduct407217 (Entrez Gene)
ELF3GeneProduct508503 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
ELK4GeneProduct540309 (Entrez Gene)
EPN1GeneProduct782204 (Entrez Gene)
EPPK1GeneProduct
EPS15GeneProduct535998 (Entrez Gene)
EPS15L1GeneProduct506374 (Entrez Gene)
EPS8GeneProduct538419 (Entrez Gene)
ERRFI1GeneProduct516303 (Entrez Gene)
FOSGeneProduct280795 (Entrez Gene)
GAB1GeneProduct540085 (Entrez Gene)
GAB2GeneProduct529346 (Entrez Gene)
GIT1GeneProduct515088 (Entrez Gene)
GJA1GeneProduct281193 (Entrez Gene)
GRB14GeneProduct497029 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GRB7GeneProduct508847 (Entrez Gene)
Grb10GeneProduct407210 (Entrez Gene)
HAT1GeneProduct509329 (Entrez Gene)
HDAC1GeneProduct404126 (Entrez Gene)
HIP1GeneProduct505919 (Entrez Gene)
HIST3H3GeneProduct
HRASGeneProduct513012 (Entrez Gene)
HTTGeneProduct615059 (Entrez Gene)
INPPL1GeneProduct783833 (Entrez Gene)
ITCHGeneProduct508431 (Entrez Gene)
JAK1GeneProduct537201 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
JUNDGeneProduct517192 (Entrez Gene)
KLF11GeneProduct616730 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
KRT17GeneProduct281889 (Entrez Gene)
KRT18GeneProduct506480 (Entrez Gene)
KRT7GeneProduct535697 (Entrez Gene)
KRT8GeneProduct281269 (Entrez Gene)
LOC100138040GeneProduct100138040 (Entrez Gene)
LOC506618GeneProduct506618 (Entrez Gene)
LOC537396GeneProduct537396 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP2K3GeneProduct516039 (Entrez Gene)
MAP2K5GeneProduct
MAP2K7GeneProduct787278 (Entrez Gene)
MAP3K14GeneProduct508367 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K2GeneProduct504592 (Entrez Gene)
MAP3K3GeneProduct508943 (Entrez Gene)
MAP3K4GeneProduct511779 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK7GeneProduct537703 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MCF2GeneProduct532185 (Entrez Gene)
MTA2GeneProduct515389 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
NCK1GeneProduct536154 (Entrez Gene)
NCK2GeneProduct526430 (Entrez Gene)
NDUFA13GeneProduct338084 (Entrez Gene)
NRASGeneProduct506322 (Entrez Gene)
PAK1GeneProduct533729 (Entrez Gene)
PEBP1GeneProduct
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CBGeneProduct517948 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PIK3R3GeneProduct286865 (Entrez Gene)
PITPNAGeneProduct616550 (Entrez Gene)
PKN2GeneProduct519754 (Entrez Gene)
PLCG1GeneProduct281987 (Entrez Gene)
PLCG2GeneProduct281988 (Entrez Gene)
PLD1GeneProduct514554 (Entrez Gene)
PLD2GeneProduct522159 (Entrez Gene)
PLEC1GeneProduct
PLSCR1GeneProduct513193 (Entrez Gene)
PRKAR1AGeneProduct615074 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCIGeneProduct528478 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PRKD1GeneProduct533270 (Entrez Gene)
PTK2BGeneProduct541008 (Entrez Gene)
PTK6GeneProduct529814 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN12GeneProduct531877 (Entrez Gene)
PTPN5GeneProduct615850 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
PTPRRGeneProduct536337 (Entrez Gene)
PXNGeneProduct517456 (Entrez Gene)
RAB5AGeneProduct539764 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RALBGeneProduct505238 (Entrez Gene)
RALBP1GeneProduct523324 (Entrez Gene)
RALGDSGeneProduct783943 (Entrez Gene)
RASA1GeneProduct282032 (Entrez Gene)
RBBP7GeneProduct537402 (Entrez Gene)
REPS1GeneProduct536155 (Entrez Gene)
REPS2GeneProduct526887 (Entrez Gene)
RFXANKGeneProduct100125917 (Entrez Gene)
RGS16GeneProduct282035 (Entrez Gene)
RIPK1GeneProduct504727 (Entrez Gene)
RPS6KA1GeneProduct533908 (Entrez Gene)
RPS6KA2GeneProduct517953 (Entrez Gene)
RPS6KA3GeneProduct511190 (Entrez Gene)
RPS6KA5GeneProduct504408 (Entrez Gene)
SH2D3CGeneProduct515820 (Entrez Gene)
SH3BGRLGeneProduct614007 (Entrez Gene)
SH3GL2GeneProduct512450 (Entrez Gene)
SH3GL3GeneProduct520311 (Entrez Gene)
SH3KBP1GeneProduct510489 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SHOC2GeneProduct511417 (Entrez Gene)
SIN3AGeneProduct518504 (Entrez Gene)
SMAD2GeneProduct516010 (Entrez Gene)
SMAD3GeneProduct515125 (Entrez Gene)
SNCAGeneProduct282857 (Entrez Gene)
SNRPD2GeneProduct514932 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SP1GeneProduct540741 (Entrez Gene)
SPRY2GeneProduct539090 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT2GeneProduct511023 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
STXBP1GeneProduct282378 (Entrez Gene)
TGIF1GeneProduct510050 (Entrez Gene)
TNIP1GeneProduct526103 (Entrez Gene)
TNK2GeneProduct
USP6NLGeneProduct530462 (Entrez Gene)
VAV1GeneProduct617345 (Entrez Gene)
VAV2GeneProduct
VAV3GeneProduct521961 (Entrez Gene)
WASLGeneProduct281577 (Entrez Gene)
WNK1GeneProduct506433 (Entrez Gene)
YWHABGeneProduct286863 (Entrez Gene)
ZNF259GeneProduct504523 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP978"
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