Cell cycle (Mus musculus)

From WikiPathways

Revision as of 00:20, 2 March 2011 by MaintBot (Talk | contribs)
Jump to: navigation, search
+p+p+pR-pointAPC/C+pe(Start)+pSCFsignalingSeApoptosisMaintenance) complexORC (OriginDNAMAPKp21E2FUbiquitinmediated+pTranscription Factor E2F+u+u+p-p+pS-phase proteins+up27,57G1Recognition Complex)Mwithdrawalepathway+p+pDNA biosynthesisp16,15,18,19+uCondensineG2+uAPC/C+p+p+pORCDNA damage checkpoint-pSCFeGrowth FactorDNAMCM+p+pSeparinproteolysisHistone Deacetylases+pSecurin+pGrowth FactorMCM (Mini-ChromosomeHDACMcm6Cdc25bOrc2lMad2l2E2f6Orc4lMcm4Mad2l1CcnhHdac1-psRb1Tfdp1Cdc45lMdm2Cdc25aCcnb1Espl1Tgfb1MENPkmyt1E2f5Hdac5Hdac3E2f1Tbc1d8PcnaBub1bCcnb3Cdkn2aRbl1Ccnd2Cdk2E2f3Orc1l14-3-3YwhagPttg1ARFCdh1Abl1Cdc2aBub1Ep300Rbl1Mcm5Cdkn1aCcna2Mcm3Orc3lCdc7Ccne1Cdc20Ccnb2Cdc2aHdac2Ccna1Wee1Skp2Cdk2Ccna2Ccne2Cdk2Orc5lCcna1AA545217Rb1Gadd45aHdac4Cdc14BMcm2Hdac7aAtrAtmPrkdcOrc6lCdk6Cdc25cHdac6Cdc6Skp2Cdkn1bCcnd3Smad3Smc1l2Cdk4Mpeg1Rb1Smad4Mad1l1Gsk3bPlk1Bub3Trp53Chek2AL118125Mcm7Cdc14AE2f2E2f4Chek1


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
GenMAPP remarks 
Right-click here to see notes

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
140217view10:10, 7 August 2025EgonwModified description
89518view11:00, 16 September 2016Mkutmonontology tag fix
89476view13:39, 15 September 2016Mkutmonremove space from ontology term id
81191view13:47, 3 August 2015Mkutmonfix invalid xref
71755view20:20, 17 October 2013MaintBotUpdated data sources
67102view10:06, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
62828view04:41, 3 May 2013MaintBotupdated uniprot data source
41247view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
35363view09:13, 12 February 2010MartijnVanIerselModified description
34372view22:42, 9 December 2009MaintBotAutomatic update of empty xrefs
21079view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Cell cycle KEGG]] moved to [[Pathway:WP190]]: Moved to stable identifier
10210view18:28, 16 January 2008MaintBotSpecify description
19398view13:26, 11 January 2008BruceConklinrestored missing GPML
10045view13:26, 11 January 2008Nsalomonisrestored missing GPML

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
AA545217GeneProduct27214 (Entrez Gene) ASK; activator of S phase kinas
AL118125GeneProduct404565 (Entrez Gene)
  • «208727[L] »
  • Hdac4; histone deacetylase 4
ARFGeneProduct
Abl1GeneProduct11350 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
AtmGeneProduct11920 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
AtrGeneProduct245000 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
Bub1GeneProduct12235 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
Bub1bGeneProduct12236 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Bub3GeneProduct12237 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
Ccna1GeneProduct12427 (Entrez Gene) CCNA1; cyclin A1
Ccna2GeneProduct12428 (Entrez Gene) CCNA2; cyclin A2
Ccnb1GeneProduct268697 (Entrez Gene)
Ccnb2GeneProduct12442 (Entrez Gene) CCNB2; cyclin B2
Ccnb3GeneProduct209091 (Entrez Gene) CCNB3; cyclin B - see SP:Q8VDC5
Ccnd2GeneProduct12444 (Entrez Gene) CCND2; cyclin D2
Ccnd3GeneProduct12445 (Entrez Gene) CCND3; cyclin D3
Ccne1GeneProduct12447 (Entrez Gene) CCNE1; cyclin E
Ccne2GeneProduct12448 (Entrez Gene) CCNE2; cyclin E
CcnhGeneProduct66671 (Entrez Gene) CCNH; cyclin H
Cdc14AGeneProduct229776 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
Cdc14BGeneProduct218294 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
Cdc20GeneProduct107995 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
Cdc25aGeneProduct12530 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
Cdc25bGeneProduct12531 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
Cdc25cGeneProduct12532 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
Cdc2aGeneProduct12534 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
Cdc45lGeneProduct12544 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
Cdc6GeneProduct23834 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
Cdc7GeneProduct12545 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
Cdh1GeneProduct12550 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
Cdk4GeneProduct12567 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
Cdk6GeneProduct12571 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
Cdkn1aGeneProduct12575 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
Cdkn1bGeneProduct12576 (Entrez Gene)
Cdkn2aGeneProduct12578 (Entrez Gene)
Chek1GeneProduct12649 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Chek2GeneProduct50883 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
E2f1GeneProduct13555 (Entrez Gene) E2F1; E2F transcription factor 1
E2f2GeneProduct242705 (Entrez Gene) E2F2; E2F transcription factor 2
E2f3GeneProduct13557 (Entrez Gene) E2F3; E2F transcription factor 3
E2f4GeneProduct104394 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2f5GeneProduct13559 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2f6GeneProduct50496 (Entrez Gene) E2F6; E2F transcription factor 6
Ep300GeneProduct328572 (Entrez Gene) EP300; E1A binding protein p300
Espl1GeneProduct105988 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
Gadd45aGeneProduct13197 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
Hdac1-psGeneProduct15181 (Entrez Gene) HDAC1; histone deacetylase 1
Hdac2GeneProduct15182 (Entrez Gene) HDAC2; histone deacetylase 2
Hdac3GeneProduct15183 (Entrez Gene) HDAC3; histone deacetylase 3
Hdac4GeneProduct208727 (Entrez Gene)
  • «208727[L] »
  • Hdac4; histone deacetylase 4
Hdac5GeneProduct15184 (Entrez Gene) HDAC5; histone deacetylase 5
Hdac6GeneProduct15185 (Entrez Gene) HDAC6; histone deacetylase 6
Hdac7aGeneProduct56233 (Entrez Gene) HDAC7A; histone deacetylase 7
MENGeneProduct
Mad1l1GeneProduct17120 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
Mad2l1GeneProduct56150 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
Mad2l2GeneProduct71890 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
Mcm2GeneProduct17216 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
Mcm3GeneProduct17215 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
Mcm4GeneProduct17217 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
Mcm5GeneProduct17218 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
Mcm6GeneProduct17219 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
Mcm7GeneProduct17220 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
Mdm2GeneProduct17246 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
Mpeg1GeneProduct17476 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
Orc2lGeneProduct18393 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
Orc3lGeneProduct50793 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
Orc4lGeneProduct26428 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
Orc5lGeneProduct26429 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
Orc6lGeneProduct56452 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PcnaGeneProduct18538 (Entrez Gene) PCNA; proliferating cell nuclear antigen
Pkmyt1GeneProduct268930 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
Plk1GeneProduct18817 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PrkdcGeneProduct19090 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
Pttg1GeneProduct30939 (Entrez Gene) PTTG1; pituitary tumor-transforming
Rb1GeneProduct19645 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
Rbl1GeneProduct19650 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
Skp2GeneProduct27401 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
Smad3GeneProduct17127 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
Smad4GeneProduct17128 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
Smc1l2GeneProduct140557 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
Tbc1d8GeneProduct54610 (Entrez Gene)
Tfdp1GeneProduct21781 (Entrez Gene) TFDP1; transcription factor Dp-1
Tgfb1GeneProduct21803 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Wee1GeneProduct22390 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YwhagGeneProduct22628 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP190"