DNA replication (Danio rerio)

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DNA polymerase alpha: primase: origin complexMcm7DNA PolymeraseRNA primer-DNA primerOriginPre-replicative complexUbiquitinated Cdc6PCNA homotrimerp49Mcm3Cdc6Phosphorylated Orc1dCTPp180ATPRNA Primerwith the replication forkPrimasep70dUTPGTPUbiquitinRFC140Mcm6ATPRFC38CTPUbiquitinated Orc1Orc1RFC Heteropentamer:RNA primer-DNA primerRFC40Orc complexMcm4Orc5Degraded by proteasome in cytosolMcm2ADPCdt1Mcm10Orc32. Activation of the pre-replicative complexMcm2RNA primer-DNA primerRNA primer-DNA primer:origin duplex:PCNAADPCdt1Orc4Orc3Orc2Degraded by proteasome in cytosolHOMOLOGY MAPP4. Switching of origins to post-replicative statedATPOrc2UTPRFC36Pre-replicative complexp58Phosphorylation of Mcm 2-7 complexdGTPCdt1Orc2Cdc6ATPMcm6Orc4Orc3Processive complexOrc33. DNA replication initiationUbiquitinMcm5Mcm4Cdt1Cdc6Orc5Cdc6DNA polymerase alpha: primase: origin complex5. Leading/lagging strand synthesisOrc complexGemininRFC37Orc ComplexOrc2Mcm5Orc complexCdt1Mcm3RFC Heteropentamer:RNA primer-DNA primer:Mcm7ATPOrc complexMcm 4,6,7 trimer forms and associatesaPhosphorylated Cdc6Orc51. Assembly of the pre-replicative complexPOLE2orc6lPOLAASKgmnnPOLEzgc:77827CDC6POLD1RFC1zgc:85772prim1orc1lpcnazgc:56598ORC2LPOLD3UBCMCM10rpa2orc3lzgc:110810zgc:56264CDT1rfc5mcm2RPA4zgc:101602mcm4pold2rfc3rfc4zgc:110727UBA52rpa1zgc:56310zgc:77841mcm5MCM7mcm3POLD4MCM6


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139037view19:28, 12 May 2025KhanspersModified description
116856view10:52, 14 May 2021EweitzModified title
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC6GeneProduct
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2LGeneProduct
POLAGeneProduct
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProduct
RPA4GeneProduct
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProduct
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
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