Caffeine in neurons (Homo sapiens)

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Description

Caffeine acts as a competitive antagonist at adenosine receptors -- particularly the A₁ and A₂A subtypes -- thereby promoting wakefulness and modifying the activity of key neurotransmitters, including dopamine, epinephrine, norepinephrine, and serotonin, within the central nervous system. Inspired by [Figure 1 in Kumar and Lipshultz, 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6915633).

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Ontology Terms

 

Bibliography

  1. Kumar VHS, Lipshultz SE; ''Caffeine and Clinical Outcomes in Premature Neonates.''; Children (Basel), 2019 PubMed Europe PMC Scholia

History

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141493view01:01, 16 November 2025EweitzClear cached dimensions
141492view00:58, 16 November 2025EweitzEconomize layout
141491view00:54, 16 November 2025EweitzRefine width
141490view00:50, 16 November 2025EweitzAdd identifiers
141317view13:05, 9 November 2025EweitzAdd literature reference
141247view04:26, 7 November 2025EweitzOntology Term : 'caffeine metabolic pathway' added !
141246view04:26, 7 November 2025EweitzOntology Term : 'caffeine drug pathway' added !
141245view04:25, 7 November 2025EweitzOntology Term : 'central nervous system neuron' added !
141244view04:25, 7 November 2025EweitzOntology Term : 'neuron' added !
141243view04:19, 7 November 2025EweitzRefine graphics
141242view04:12, 7 November 2025EweitzModified description
141241view04:12, 7 November 2025EweitzModified description
141238view03:31, 7 November 2025EweitzRefine padding, spacing
141237view03:30, 7 November 2025EweitzRefine graphics
141236view03:29, 7 November 2025EweitzAdd pathway series navigation
141235view03:18, 7 November 2025EweitzAlign nodes
141234view03:17, 7 November 2025EweitzAlign nodes
141233view03:16, 7 November 2025EweitzEconomize layout
141232view03:15, 7 November 2025EweitzEconomize layout
141231view03:14, 7 November 2025EweitzAlign nodes
141230view03:13, 7 November 2025EweitzAdd state transition
141229view03:12, 7 November 2025EweitzAdd caffeinated state
141228view02:42, 7 November 2025EweitzRefine interactions
141227view02:35, 7 November 2025EweitzAdd interactions
141225view00:32, 7 November 2025EweitzRefine graphics
141224view00:31, 7 November 2025EweitzAdd conditions
141222view00:15, 7 November 2025EweitzAdd metabolites, genes
141221view23:55, 6 November 2025EweitzAdd A1R and A2AR
141220view23:53, 6 November 2025EweitzAdd vesicles, labels
141218view23:29, 6 November 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADORA2AGeneProductENSG00000128271 (Ensembl) "A3" in source
ADRA1AGeneProductENSG00000120907 (Ensembl) "A1" in source
ADRA1BGeneProductENSG00000170214 (Ensembl) "A1" in source
ADRA1DGeneProductENSG00000171873 (Ensembl) "A1" in source
AdenosineMetaboliteCHEBI:16335 (ChEBI)
ArousalQ379784 (Wikidata)
Blood vesselsPathwayWP5601 (WikiPathways)
CaffeineMetaboliteCHEBI:27732 (ChEBI)
GABAMetaboliteCHEBI:16865 (ChEBI)
MyocytesPathwayWP5603 (WikiPathways)
NTMetaboliteCHEBI:25512 (ChEBI)
NeuronsPathwayWP5602 (WikiPathways)
Neurotransmitter releaseQ14863664 (Wikidata)
Signal transmissionQ14914309 (WikiPathways)
Sleep

Annotated Interactions

No annotated interactions

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