HINT1 pathway (Homo sapiens)

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Description

HINT1 is a protein that can be mutated in charcot marie tooth disease.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Peeters K, Chamova T, Tournev I, Jordanova A; ''Axonal neuropathy with neuromyotonia: there is a HINT.''; Brain, 2017 PubMed Europe PMC Scholia
  2. Ozga M, Dolot R, Janicka M, Kaczmarek R, Krakowiak A; ''Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5'-O-phosphorothioates to nucleoside 5'-O-phosphates.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  3. Wang J, Fang P, Schimmel P, Guo M; ''Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor.''; J Phys Chem B, 2012 PubMed Europe PMC Scholia
  4. Weiske J, Huber O; ''The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription.''; J Cell Sci, 2005 PubMed Europe PMC Scholia
  5. Martin J, St-Pierre MV, Dufour JF; ''Hit proteins, mitochondria and cancer.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  6. Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB; ''Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells.''; Cancer Res, 2007 PubMed Europe PMC Scholia
  7. Wang L, Li H, Zhang Y, Santella RM, Weinstein IB; ''HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells.''; Int J Cancer, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141965view16:23, 28 November 2025EweitzUse gene symbol
141964view16:22, 28 November 2025EweitzStandardize case
141963view16:20, 28 November 2025EweitzEconomize layout
139066view07:02, 18 May 2025EgonwAnother complex
139065view07:01, 18 May 2025EgonwMade two pathways clickable
139064view07:00, 18 May 2025EgonwAdded two missing datasources
139063view06:59, 18 May 2025EgonwOntology Term : 'Charcot-Marie-Tooth disease' added !
139062view06:58, 18 May 2025EgonwOntology Term : 'disease pathway' added !
139006view20:22, 10 May 2025EweitzModified title
138149view17:22, 18 March 2025Julen van HamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3'-lysyl-AMPMetaboliteCHEBI:131569 (ChEBI)
5'-AMPMetaboliteCHEBI:16027 (ChEBI)
AP1 complexComplexCPX-480
ATP-sensitive potassium channels pathwayPathwayWP2669 (WikiPathways)
ATPMetaboliteCHEBI:30616 (ChEBI)
CDK7GeneProductENSG00000134058 (Ensembl)
CTNNB1GeneProductP35222 (Uniprot-TrEMBL)
ERCC2GeneProductP18074 (Uniprot-TrEMBL)
ERCC3GeneProductP19447 (Uniprot-TrEMBL)
FOSGeneProductP01100 (Uniprot-TrEMBL)
Guanosine 5'-monophosphorothioateMetabolite135405922 (PubChem-compound)
HINT1GeneProductENSG00000169567 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KARS1GeneProductENSG00000065427 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAT1GeneProductP51948 (Uniprot-TrEMBL)
MITFGeneProductENSG00000187098 (Ensembl)
NFATC2GeneProductQ13469 (Uniprot-TrEMBL)
NFκB1GeneProductP19838 (Uniprot-TrEMBL)
RUVB1GeneProductQ9Y265 (Uniprot-TrEMBL)
RUVB2GeneProductQ9Y230 (Uniprot-TrEMBL)
SH3RF1GeneProductENSG00000154447 (Ensembl)
TCF4GeneProductP15884 (Uniprot-TrEMBL)
TF2H1GeneProductP32780 (Uniprot-TrEMBL)
TF2H2GeneProductQ13888 (Uniprot-TrEMBL)
TF2H3GeneProductQ13889 (Uniprot-TrEMBL)
TF2H4GeneProductQ92759 (Uniprot-TrEMBL)
TF2H5GeneProductQ6ZYL4 (Uniprot-TrEMBL)
TFIIH complexComplexCPX-2395
USF2GeneProductENSG00000105698 (Ensembl)
cyclin HGeneProductP51946 (Uniprot-TrEMBL)
lysineMetaboliteCHEBI:25094 (ChEBI)
tRNA AminoacylationPathwayWP1938 (WikiPathways)

Annotated Interactions

No annotated interactions

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