Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity (Homo sapiens)

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Description

Quality Tags

Ontology Terms

Bibliography

1. Dierichs NTOM, Piersma AH, Peeters RP, Visser WE, Meima ME, Hessel EVS; ''Mechanisms of developmental neurotoxicity mediated by perturbed thyroid hormone homeostasis in the brain: an adverse outcome pathway network.''; Crit Rev Toxicol, 2025 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	138127	view	15:43, 16 March 2025	Marvin M2	Added reference to main paper
	137486	view	21:47, 2 March 2025	Marvin M2	Ontology Term : 'oligodendrocyte' added !
	137485	view	21:47, 2 March 2025	Marvin M2	Ontology Term : 'neuron' added !
	137484	view	21:46, 2 March 2025	Marvin M2	Ontology Term : 'neurodevelopmental disorder pathway' added !
	137483	view	21:45, 2 March 2025	Marvin M2	Ontology Term : 'DOID:1561' removed !
	137482	view	21:45, 2 March 2025	Marvin M2	Ontology Term : 'cognitive disorder' added !
	137481	view	21:44, 2 March 2025	Marvin M2	Modified description
	137480	view	21:40, 2 March 2025	Marvin M2	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
Abnormal white matter	Key Event
Altered myelin gene expression	Key Event
BDNF signaling pathway	Pathway	WP2380 (WikiPathways)
Cell cycle	Pathway	WP179 (WikiPathways)
Decreased T3/T4 availability	Key Event	280 (AOP-Wiki KE)
Decreased axon insulation	Key Event
Decreased cell proliferation	Key Event
Decreased cognition
Decreased membrane transport of T3	Key Event
Decreased motor function
Decreased network formation	Key Event
Decreased neural network communication
Decreased synaptogenesis	Key Event	385 (AOP-Wiki KE)
Hippocampal synaptogenesis and neurogenesis	Pathway	WP5231 (WikiPathways)
Hypomyelination		2107 (AOP-Wiki KE)
Oligodendrocyte specification and differentiation, leading to myelin components for CNS	Pathway	WP4304 (WikiPathways)
Reduced activation TRa1	Key Event
Reduced levels of BDNF	Key Event	381 (AOP-Wiki KE)
Reduced levels of intracellular T3	Key Event
SLC16A10	GeneProduct	117247 (Entrez Gene)
SLC16A2	GeneProduct	6567 (Entrez Gene)
SLC7A5	GeneProduct	8140 (Entrez Gene)
SLC7A8	GeneProduct	23428 (Entrez Gene)
SLCO1A2	GeneProduct	6579 (Entrez Gene)
SLCO1C1	GeneProduct	53919 (Entrez Gene)
SLCO3A1	GeneProduct	28232 (Entrez Gene)
SLCO4A1	GeneProduct	28231 (Entrez Gene)

Annotated Interactions

No annotated interactions