N-glycan biosynthesis (Homo sapiens)

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1, 3, 422ER lumenGDP-D-mannoseDolichyl phosphate D-mannoseSTT3BDolicholDOLPP1G10595DAD1ALG10RFT1Dolichyl diphosphatePolyprenolFructose-6-phosphateMOGSMPDU1GANABMAN1B1MGAT1MAN1A1MAN2A1MAN1A2MAN1C1MAN2A2MGAT2MGAT3FUT8B4GALT1B4GALT2B4GALT3ST6GAL1ST6GAL2G00171G00010G00011G10694G00012G00013G00014G00015G00019G00020G00016MGAT5G00021G00022MGAT4CG00017G00018ALG8ALG6ALG9ALG12ALG3G10596G10597G00007G10598G10599G00008STT3ADDOSTRPN1RPN2TUSC3G00006G00009Dolichyl phosphateDOLKSRD5A3DPAGT1ALG13ALG14ALG1ALG2ALG11G00001G00002G00003G00004G00005G10526G00006DPM1DPM2DPM3MPDU1Dolichyl β-D-glucosyl phosphateDolichyl phosphateALG5dolichyl phosphateGMPPAGMPPBPMM2MPIGPIGlucose 6-phosphateMannose-6-phosphateD-mannose 1-phosphateCytoplasmGolgiG10694MGAT4BMGAT4AMGAT4DMGAT5BALG10B


Description

This pathways describes the biosynthesis of N-linked (Asparagine-linked) glycans, to form glycoproteins. This process is a type of co-translational and post-translational modification and sometimes referred to as N-linked glycosylation. Glycosylation is important for many processes, including protein folding and cell-cell adhesion and immune function. This pathway was modeled based on Figure 9.3 and 9.4 from Essentials of Glycobiology [Internet. 3rd edition], Figure 17.1 from Dall'Olio and KEGG.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kranz C, Denecke J, Lehrman MA, Ray S, Kienz P, Kreissel G, Sagi D, Peter-Katalinic J, Freeze HH, Schmid T, Jackowski-Dohrmann S, Harms E, Marquardt T; ''A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If).''; J Clin Invest, 2001 PubMed Europe PMC Scholia
  2. ''N-Glycan biosynthesis - Homo sapiens (human)''; https://www.kegg.jp/entry/pathway+hsa00510,
  3. Varki A, Cummings RD, Esko JD, et al., editors; ''Essentials of Glycobiology [Internet]. 3rd edition.''; https://www.ncbi.nlm.nih.gov/books/NBK453020/, 2017 PubMed Europe PMC Scholia
  4. Dall'Olio F; ''Glycobiology of Aging.''; Subcell Biochem, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137687view05:14, 7 March 2025EgonwModified description
134712view12:26, 26 July 2024EweitzFix truncated text in node, standardize case
134711view12:24, 26 July 2024EweitzStandardize case
127636view10:39, 11 November 2023EgonwAdded the identifier
127082view11:06, 30 July 2023EgonwModified description
126751view13:25, 18 June 2023EgonwAdded the chapter's PubMed ID.
125991view19:15, 23 March 2023KhanspersModified description
125990view18:58, 23 March 2023Khansperslatest - updated xrefs, labels
120567view20:42, 16 December 2021KhanspersOntology Term : 'protein modification pathway' added !
120566view20:42, 16 December 2021KhanspersOntology Term : 'N-linked glycan biosynthetic pathway' added !
120565view20:39, 16 December 2021KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALG10BGeneProductENSG00000175548 (Ensembl)
ALG10GeneProductENSG00000139133 (Ensembl)
ALG11GeneProductENSG00000253710 (Ensembl)
ALG12GeneProductENSG00000182858 (Ensembl)
ALG13GeneProductENSG00000101901 (Ensembl)
ALG14GeneProductENSG00000172339 (Ensembl)
ALG1GeneProductENSG00000033011 (Ensembl)
ALG2GeneProductENSG00000119523 (Ensembl)
ALG3GeneProductENSG00000214160 (Ensembl)
ALG5GeneProductENSG00000120697 (Ensembl)
ALG6GeneProductENSG00000088035 (Ensembl)
ALG8GeneProductENSG00000159063 (Ensembl)
ALG9GeneProductENSG00000086848 (Ensembl)
B4GALT1GeneProductENSG00000086062 (Ensembl)
B4GALT2GeneProductENSG00000117411 (Ensembl)
B4GALT3GeneProductENSG00000158850 (Ensembl)
D-mannose 1-phosphateMetaboliteCHEBI:35374 (ChEBI)
DAD1GeneProductENSG00000129562 (Ensembl)
DDOSTGeneProductENSG00000244038 (Ensembl)
DOLKGeneProductENSG00000175283 (Ensembl)
DOLPP1GeneProductENSG00000167130 (Ensembl)
DPAGT1GeneProductENSG00000172269 (Ensembl)
DPM1GeneProductENSG00000000419 (Ensembl)
DPM2GeneProductENSG00000136908 (Ensembl)
DPM3GeneProductENSG00000179085 (Ensembl)
DolicholMetaboliteCHEBI:88766 (ChEBI)
Dolichyl diphosphateMetaboliteHMDB01513 (HMDB)
Dolichyl phosphate D-mannoseMetaboliteHMDB00994 (HMDB)
Dolichyl phosphateMetaboliteCHEBI:16214 (ChEBI)
Dolichyl β-D-glucosyl phosphateMetaboliteCHEBI:15812 (ChEBI)
FUT8GeneProductENSG00000033170 (Ensembl)
Fructose-6-phosphateMetaboliteHMDB0000124 (HMDB)
G00001MetaboliteG00001 (KEGG Glycan)
G00002MetaboliteG00002 (KEGG Glycan)
G00003MetaboliteG00003 (KEGG Glycan)
G00004MetaboliteG00004 (KEGG Glycan)
G00005MetaboliteG00005 (KEGG Glycan)
G00006MetaboliteG00006 (KEGG Glycan)
G00007MetaboliteG00007 (KEGG Glycan)
G00008MetaboliteG00008 (KEGG Glycan)
G00009MetaboliteG00009 (KEGG Glycan)
G00010MetaboliteG00010 (KEGG Glycan)
G00011MetaboliteG00011 (KEGG Glycan)
G00012MetaboliteG00012 (KEGG Glycan)
G00013MetaboliteG00013 (KEGG Glycan)
G00014MetaboliteG00014 (KEGG Glycan)
G00015MetaboliteG00015 (KEGG Glycan)
G00016MetaboliteG00016 (KEGG Glycan)
G00017MetaboliteG00017 (KEGG Glycan)
G00018MetaboliteG00018 (KEGG Glycan)
G00019MetaboliteG00019 (KEGG Glycan)
G00020MetaboliteG00020 (KEGG Glycan)
G00021MetaboliteG00021 (KEGG Glycan)
G00022MetaboliteG00022 (KEGG Glycan)
G00171MetaboliteG00171 (KEGG Glycan)
G10526MetaboliteG10526 (KEGG Glycan)
G10595MetaboliteG10595 (KEGG Glycan)
G10596MetaboliteG10596 (KEGG Glycan)
G10597MetaboliteG10597 (KEGG Glycan)
G10598MetaboliteG10598 (KEGG Glycan)
G10599MetaboliteG10599 (KEGG Glycan)
G10694MetaboliteG10694 (KEGG Glycan)
GANABGeneProductENSG00000089597 (Ensembl)
GDP-D-mannoseMetaboliteCHEBI:84880 (ChEBI)
GMPPAGeneProductENSG00000144591 (Ensembl)
GMPPBGeneProductENSG00000173540 (Ensembl)
GPIGeneProductENSG00000105220 (Ensembl)
Glucose 6-phosphateMetaboliteHMDB0001401 (HMDB)
MAN1A1GeneProductENSG00000111885 (Ensembl)
MAN1A2GeneProductENSG00000198162 (Ensembl)
MAN1B1GeneProductENSG00000177239 (Ensembl)
MAN1C1GeneProductENSG00000117643 (Ensembl)
MAN2A1GeneProductENSG00000112893 (Ensembl)
MAN2A2GeneProductENSG00000196547 (Ensembl)
MGAT1GeneProductENSG00000131446 (Ensembl)
MGAT2GeneProductENSG00000168282 (Ensembl)
MGAT3GeneProductENSG00000128268 (Ensembl)
MGAT4AGeneProduct11320 (Entrez Gene)
MGAT4BGeneProductMGAT4B (HGNC)
MGAT4CGeneProductENSG00000182050 (Ensembl)
MGAT4DGeneProduct152586 (Entrez Gene)
MGAT5BGeneProduct146664 (Entrez Gene)
MGAT5GeneProductENSG00000152127 (Ensembl)
MOGSGeneProductENSG00000115275 (Ensembl)
MPDU1GeneProductENSG00000129255 (Ensembl)
MPIGeneProductENSG00000178802 (Ensembl)
Mannose-6-phosphateMetaboliteHMDB0001078 (HMDB)
PMM2GeneProductENSG00000140650 (Ensembl)
PolyprenolMetaboliteCHEBI:26199 (ChEBI)
RFT1GeneProductENSG00000163933 (Ensembl)
RPN1GeneProductENSG00000163902 (Ensembl)
RPN2GeneProductENSG00000118705 (Ensembl)
SRD5A3GeneProductENSG00000128039 (Ensembl)
ST6GAL1GeneProductENSG00000073849 (Ensembl)
ST6GAL2GeneProductENSG00000144057 (Ensembl)
STT3AGeneProductENSG00000134910 (Ensembl)
STT3BGeneProductENSG00000163527 (Ensembl)
TUSC3GeneProductENSG00000104723 (Ensembl)
dolichyl phosphateMetaboliteCHEBI:16214 (ChEBI)

Annotated Interactions

No annotated interactions

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