Kinin-Kallikrein pathway (Homo sapiens)

Revision as of 02:14, 10 March 2024 by Eweitz (Talk | contribs)

Description

Kinin Kallikrein Pathway that leads to Bradykinin receptor 1 (BDKRB1) and receptor 2 (BDKRB2) activation in homo sapiens starting from FXII

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Bryant JW, Shariat-Madar Z; ''Human plasma kallikrein-kinin system: physiological and biochemical parameters.''; Cardiovasc Hematol Agents Med Chem, 2009 PubMed Europe PMC Scholia
Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, Mast AE, Justice A, Aronow B, Jacobson D; ''A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm.''; Elife, 2020 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
139850	view	08:47, 8 July 2025	Ddigles	Merged descriptions
129066	view	02:53, 10 March 2024	Eweitz	Use gene symbols, standardize case
129063	view	02:14, 10 March 2024	Eweitz	Modified description
129062	view	02:13, 10 March 2024	Eweitz	Economize layout
118192	view	11:43, 25 May 2021	Ariajadhav	Updated pathway data nodes
117971	view	11:02, 23 May 2021	Eweitz	Modified title
116322	view	11:37, 30 April 2021	Marvin M2	Ontology Term : 'kallikrein-kinin cascade pathway' added !
116313	view	15:13, 29 April 2021	Ariajadhav	New pathway

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Name	Type	Database reference
BDKRB1	Protein	G3V4Y2 (Uniprot-TrEMBL)
BDKRB2	Protein	624 (Entrez Gene)
Bradykinin	Protein	9606 (NCBI Protein)
CPN1	GeneProduct	ENSG00000120054 (Ensembl)
Coagulation factor XII	Protein	P00748 (Uniprot-TrEMBL)
KLKB1	GeneProduct	ENSG00000164344 (Ensembl)
Kininogen-1	Protein	P01042 (Uniprot-TrEMBL)
SERPING1	GeneProduct	ENSG00000149131 (Ensembl)
des-arg(9) bradykinin	Metabolite	133068 (ChEBI)

No annotated interactions