NIPBL role in DNA damage - Cornelia de Lange syndrome (Homo sapiens)

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3322222232ICLCBX3NIPBLATMATRNIPBLHistone H2AXRNF8RNF168MDC1NIPBL role in DNA damage1, 2DSBDSB2ICLRNF8RNF168UbiquitinLegendChromatidDSBRecruitmentHistone H2AXMDC13RNF1683RNF82222ICLInterstrand cross linkDSBDouble strand break


Description

Recruitment of cohesin subunit NIPBL after DNA damage.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Oka Y, Suzuki K, Yamauchi M, Mitsutake N, Yamashita S; ''Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells.''; Biochem Biophys Res Commun, 2011 PubMed Europe PMC Scholia
  2. Bot C, Pfeiffer A, Giordano F, Manjeera DE, Dantuma NP, Ström L; ''Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage.''; J Cell Sci, 2017 PubMed Europe PMC Scholia
  3. Oka Y, Suzuki K, Yamauchi M, Mitsutake N, Yamashita S; ''Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells.''; Biochem Biophys Res Commun, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129305view13:47, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
128298view04:13, 30 January 2024EweitzLess margin
128297view04:12, 30 January 2024EweitzPlace legend at right of diagram, per convention
128296view04:09, 30 January 2024EweitzFurther economize layout
128295view03:31, 30 January 2024EweitzFurther economize layout
128294view03:13, 30 January 2024EweitzRefine legend, economize layout, standardize case
125320view21:50, 31 January 2023LarsgwFix reference bp:ID
119393view10:46, 27 June 2021EweitzOntology Term : 'Cornelia de Lange syndrome' added !
119392view10:46, 27 June 2021EweitzModified title
119109view12:38, 17 June 2021IrkilmezANew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
CBX3GeneProductENSG00000122565 (Ensembl)
Histone H2AXProteinP16104 (Uniprot-TrEMBL)
MDC1GeneProductENSG00000137337 (Ensembl)
NIPBLGeneProductENSG00000164190 (Ensembl)
RNF168GeneProductENSG00000163961 (Ensembl)
RNF8GeneProductENSG00000112130 (Ensembl)

Annotated Interactions

No annotated interactions

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