HIF1A and PPARG in hypertrophic cardiomyopathy (Homo sapiens)

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PyruvateMyocardial SteatosisTPI1LDHAGAPDHGlyceraldehyde-3-phosphateFructose-1,6-biphosphateDihydroxyacetonephosphateLactateGlycerol-3-phosphateLysophosphatidateTriacylglycerolDiacylglycerolGPD1GPAT3GlucoseSLC2A1PPARGHIF1AHIF1A


Description

Hypoxia-inducible factor 1A and peroxisome proliferator activated receptor gamma play a role in regulating glycolysis. This pathway is part the CPTAC Assay Portal.

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Ontology Terms

 

Bibliography

  1. Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, Tokarska-Schlattner M, Aasum E, Bogdanova A, Perriard E, Perriard JC, Larsen T, Pedrazzini T, Krek W; ''Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.''; Cell Metab, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140643view19:19, 27 September 2025EgonwH⁺ with unicode
137811view06:38, 8 March 2025EgonwModified description
136423view03:13, 2 February 2025EweitzModified title
134929view23:56, 29 July 2024EweitzModified description
134928view23:56, 29 July 2024EweitzModified description
134924view23:16, 29 July 2024EweitzRefine alignment
134923view22:58, 29 July 2024EweitzRefine layout
134922view22:55, 29 July 2024EweitzGive pathway name more bottom margin
134921view22:53, 29 July 2024EweitzAdd background pathways for context: glycolysis, triacylglyceride synthesis
134920view21:41, 29 July 2024EweitzAdd vertical space
134919view21:41, 29 July 2024EweitzEconomize layout
134918view21:37, 29 July 2024EweitzAdd link to hypertrophic cardiomyopathy: in source text, though not source figure
134917view21:14, 29 July 2024EweitzAdd more content from source
134916view12:35, 29 July 2024EweitzAdd more content from source
134915view12:20, 29 July 2024EweitzModified title
134914view03:44, 29 July 2024EweitzOntology Term : 'lipid metabolic pathway' added !
134913view03:43, 29 July 2024EweitzOntology Term : 'hypertrophic cardiomyopathy' added !
134912view03:42, 29 July 2024EweitzModified title
134911view03:36, 29 July 2024EweitzEconomize layout
134910view03:32, 29 July 2024EweitzEconomize layout
134909view03:29, 29 July 2024EweitzOntology Term : 'cardiac muscle cell' added !
134908view03:28, 29 July 2024EweitzLabel cell type
134907view03:24, 29 July 2024EweitzAdd more content from source
134906view03:18, 29 July 2024EweitzAdd more content from source
134905view03:05, 29 July 2024EweitzAdd more from source: figure 6D in PMID 19490906
134902view22:05, 28 July 2024EweitzModified description
134901view22:05, 28 July 2024EweitzModified description
134899view21:36, 28 July 2024EweitzAdd literature reference
134898view21:35, 28 July 2024EweitzRemove obsolete, incorrect "Last modified" metadata
134897view21:34, 28 July 2024EweitzEconomize layout
134896view21:25, 28 July 2024EweitzImprove alignment, economize layout
134895view21:23, 28 July 2024EweitzIncrease font size for readability
134894view21:21, 28 July 2024EweitzStandardize case
134893view21:19, 28 July 2024EweitzEconomize layout
134892view21:16, 28 July 2024EweitzRemove HIF1A interactions that have no endpoint
119185view14:09, 21 June 2021FinterlyFixed unconnected line
107555view23:50, 19 October 2019AlexanderPicoModified description
105612view04:55, 10 August 2019KhanspersModified description
96297view16:18, 7 March 2018Fehrhartfixed connection
95512view01:15, 19 December 2017Khanspersupdated xrefs and lines
89610view12:34, 20 September 2016EveloOntology Term : 'glycolysis/gluconeogenesis pathway' added !
88642view14:59, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
71255view21:00, 16 October 2013MaintBotAutomated update of data sources
62280view00:50, 27 April 2013MaintBotFixed HIF1A xref
58978view19:04, 21 February 2013Maguirre1Corrected Database References
58791view22:45, 20 February 2013MaintBotModified categories
58711view20:02, 19 February 2013Maguirre1Fixed References
58710view19:50, 19 February 2013Maguirre1Title
58709view19:49, 19 February 2013Maguirre1Periodical save, work in progress
58708view19:39, 19 February 2013Maguirre1New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DiacylglycerolMetaboliteC00165 (KEGG Compound)
Dihydroxyacetone phosphateMetaboliteC00111 (KEGG Compound)
Fructose-1,6- biphosphateMetaboliteC05378 (KEGG Compound)
GAPDHGeneProductENSG00000111640 (Ensembl)
GPAT3GeneProductENSG00000138678 (Ensembl)
GPD1GeneProductENSG00000167588 (Ensembl)
GlucoseMetaboliteC00031 (KEGG Compound)
Glyceraldehyde- 3-phosphateMetaboliteC00118 (KEGG Compound)
Glycerol-3- phosphateMetaboliteC00093 (KEGG Compound)
HIF1AGeneProductENSG00000100644 (Ensembl)
LDHAGeneProductENSG00000134333 (Ensembl)
LactateMetaboliteC00186 (KEGG Compound)
LysophosphatidateMetaboliteC00681 (KEGG Compound)
Myocardial SteatosisPathway
PPARGGeneProductENSG00000132170 (Ensembl)
PyruvateMetaboliteC00022 (KEGG Compound)
SLC2A1GeneProductENSG00000117394 (Ensembl)
TPI1GeneProductENSG00000111669 (Ensembl)
TriacylglycerolMetaboliteC00422 (KEGG Compound)

Annotated Interactions

No annotated interactions

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