G13 signaling (Homo sapiens)

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1CytokinesisActin PolymerizationFilopodia FormationActin PolymerizationStress FiberDisappearanceMembrane RufflingActin ReorganizationCell-Cell AdhesionActivated Rho A13Anti-ApoptoticContraction & Actin-MyosinInteraction, Focal AdhesionStress Fiber ContractionDisassembly of ActinGGNA13LIMK1PFN1CDC42RTKNMYBPHIQGAP2ARHGDIBDIAPH1PIK3CBARHGEF1SH3MD2PIK3CACFL2WASPIK3CDPPP1CBIQGAP1ROCK1CFL1RAC1MYL1WASLRHOARPS6KB1MAPK10ARHGDIGCITCYFIP1PKN1TNK2ROCK2RHPN2MAP3K4PIP5K2APIK3R2CALM1PAK3


Description

The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.

Source: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141731view16:43, 22 November 2025EweitzRemove deprecated metadata field
141730view16:42, 22 November 2025EweitzEconomize layout
136969view20:04, 26 February 2025KhanspersModified description
129722view01:33, 22 May 2024EweitzModified title
117113view21:41, 17 May 2021EweitzModified title
106423view22:02, 28 August 2019KhanspersModified description
105600view04:49, 10 August 2019KhanspersModified description
95116view14:55, 16 November 2017EgonwReconnected lines.
95115view14:54, 16 November 2017EgonwBroken up nested complexes.
72112view22:56, 24 October 2013AlexanderPicoCYFIP1 is synonym of P140SRA-1
72007view12:19, 24 October 2013Mkutmonfixed unconnected lines
71390view18:42, 17 October 2013MaintBotAutomated update of data sources
71274view22:30, 16 October 2013MaintBotAutomated update of data sources
63190view20:50, 8 May 2013MaintBotUpdating gpml version
62689view21:30, 1 May 2013MaintBotupdated uniprot data source
45304view20:01, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway' added !
45303view20:01, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
41220view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
35408view10:24, 12 February 2010ThomasModified description
35407view10:19, 12 February 2010Thomasfixed labels / lines, added literature
32456view17:24, 15 August 2009MaintBotFixed text labels
32138view13:57, 14 August 2009MaintBotFixed group labels
31473view21:20, 13 August 2009MaintBotFixed text labels
21780view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:G13 Signaling Pathway]] moved to [[Pathway:WP524]]: Moved to stable identifier
14478view00:07, 23 May 2008KhanspersAdded connectors, groups, metabolites
14476view23:58, 22 May 2008KhanspersPeriodical save, work in progress
12989view11:00, 17 May 2008MaintBotSticky edges patch by Sjoerd
12580view01:45, 16 May 2008KushidatSpecify description
12573view01:14, 16 May 2008KushidatPeriodical save, work in progress
12563view01:04, 16 May 2008KushidatPeriodical save, work in progress
12556view00:44, 16 May 2008KushidatPeriodical save, work in progress
8064view13:46, 7 January 2008MaintBot[[Pathway:Human:G13 Signaling Pathway]] moved to [[Pathway:Homo sapiens:G13 Signaling Pathway]]: Renaming species
7654view16:07, 18 December 2007MaintBotfixed category names
7229view12:41, 4 November 2007MaintBotAdded categories to GPML
6320view22:17, 22 May 2007A.Chowgpml file for [[Human:G13_Signaling_Pathway]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARHGDIBGeneProduct397 (Entrez Gene)
ARHGDIGGeneProduct398 (Entrez Gene)
ARHGEF1GeneProduct9138 (Entrez Gene)
CALM1GeneProduct801 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CFL1GeneProduct1072 (Entrez Gene)
CFL2GeneProduct1073 (Entrez Gene)
CITGeneProduct11113 (Entrez Gene)
CYFIP1GeneProduct23191 (Entrez Gene)
DIAPH1GeneProduct1729 (Entrez Gene)
GNA13GeneProduct10672 (Entrez Gene)
IQGAP1GeneProduct8826 (Entrez Gene)
IQGAP2GeneProduct10788 (Entrez Gene)
LIMK1GeneProduct3984 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MYBPHGeneProduct4608 (Entrez Gene)
MYL1GeneProduct4632 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
PFN1GeneProduct5216 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene) P42338
PIK3R2GeneProduct5296 (Entrez Gene)
PIP5K2AGeneProduct5305 (Entrez Gene)
PKN1GeneProduct5585 (Entrez Gene)
PPP1CBGeneProduct5500 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
RHPN2GeneProduct85415 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene) S69211
ROCK2GeneProduct9475 (Entrez Gene) BAA31594
RPS6KB1GeneProduct6198 (Entrez Gene) A41687
RTKNGeneProduct6242 (Entrez Gene)
SH3MD2GeneProduct57630 (Entrez Gene) Posh
TNK2GeneProduct10188 (Entrez Gene) S33596
WASGeneProduct7454 (Entrez Gene)
WASLGeneProduct8976 (Entrez Gene)

Annotated Interactions

No annotated interactions

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