PPAR-gamma pathway (Homo sapiens)

Revision as of 10:45, 7 May 2021 by Eweitz (Talk | contribs)

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Description

The Peroxisome Proliferator-Activated Receptor Gamma forms a heterodimer with retinoid X receptors which regulates gene expression of various genes. This pathway is based on the entry on the PPARG pathway on Nuclear Receptor Resource (https://nrresource.org/nuclear_receptors/peroxisome-proliferator-activated-receptor-gamma-pparg-nr1c3/).

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Ali AT, Hochfeld WE, Myburgh R, Pepper MS; ''Adipocyte and adipogenesis.''; Eur J Cell Biol, 2013 PubMed Europe PMC Scholia
Skat-Rørdam J, Højland Ipsen D, Lykkesfeldt J, Tveden-Nyborg P; ''A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease.''; Basic Clin Pharmacol Toxicol, 2019 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
116510	view	10:45, 7 May 2021	Eweitz	Modified title
115994	view	15:07, 27 March 2021	Jkearns445	Fixed an interaction
115712	view	21:13, 8 March 2021	Marvin M2	Ontology Term : 'signaling pathway' added !
115711	view	21:12, 8 March 2021	Marvin M2	Ontology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
115710	view	21:12, 8 March 2021	Marvin M2	Modified description
115709	view	21:10, 8 March 2021	Marvin M2	Additional target genes and literature references added
115708	view	21:01, 8 March 2021	Marvin M2	New pathway

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Name	Type	Database reference
ADIPOQ	GeneProduct	ADIPOQ (HGNC)
CD36	GeneProduct	ENSG00000135218 (Ensembl)
CEBPA	GeneProduct	CEBPA (HGNC)
CEBPB	GeneProduct	CEBPB (HGNC)
CEBPD	GeneProduct	CEBPD (HGNC)
CEBPG	GeneProduct	CEBPG (HGNC)
CREBBP	GeneProduct	ENSG00000005339 (Ensembl)
EP300	GeneProduct	EP300 (HGNC)
FABP4	GeneProduct	ENSG00000170323 (Ensembl)
IL1A	GeneProduct	ENSG00000115008 (Ensembl)
IL1B	GeneProduct	ENSG00000125538 (Ensembl)
LPL	GeneProduct	LPL (HGNC)
NCOA1	GeneProduct	ENSG00000084676 (Ensembl)
NFKB1	GeneProduct	ENSG00000109320 (Ensembl)
PCK1	GeneProduct	ENSG00000124253 (Ensembl)
PCK2	GeneProduct	ENSG00000100889 (Ensembl)
PLIN2	GeneProduct	ENSG00000147872 (Ensembl)
PPARG	GeneProduct	ENSG00000132170 (Ensembl)
PTGS2	GeneProduct	ENSG00000073756 (Ensembl)
RELA	GeneProduct	ENSG00000173039 (Ensembl)
REL	GeneProduct	ENSG00000162924 (Ensembl)
RXRA	GeneProduct	ENSG00000186350 (Ensembl)
RXRB	GeneProduct	ENSG00000204231 (Ensembl)
RXRG	GeneProduct	ENSG00000143171 (Ensembl)
TNF	GeneProduct	TNF (HGNC)

No annotated interactions