Proline and hydroxyproline pathways (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Nenad Blau, Carlo Dionisi Vici, K Michael Gibson, Marinus Duran; ''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''; Springer (ISBN-13: 978-3642403361), 2014

History

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Compare	Revision	Action	Time	User	Comment
	141015	view	06:49, 2 November 2025	Egonw	NH₃ as unicode
	140666	view	05:36, 30 September 2025	Egonw	H⁺ with unicode
	128194	view	01:30, 29 January 2024	Eweitz	Soften disease fill color
	128188	view	00:29, 29 January 2024	Eweitz	Use standard shape for metabolite nodes
	128187	view	00:26, 29 January 2024	Eweitz	Economize layout
	128185	view	23:28, 28 January 2024	Eweitz	Economize layout
	128184	view	23:13, 28 January 2024	Eweitz	Refine alignment, standardize case
	127915	view	09:45, 15 January 2024	DeSl	Annotated some more metabolites
	127914	view	09:42, 15 January 2024	DeSl	Added some more IDs for metabolites (and one protein)
	127913	view	09:36, 15 January 2024	DeSl	Started annotating metabolites
	120414	view	09:34, 30 November 2021	Fehrhart	boxed pathway node
	119103	view	09:49, 17 June 2021	Finterly	Added ISBN for book citation
	117663	view	11:54, 22 May 2021	Eweitz	Modified title
	114133	view	10:32, 23 December 2020	DeSl	Update description with fig. number.
	114128	view	10:24, 23 December 2020	DeSl	Ontology Term : 'prolidase deficiency pathway' added !
	114127	view	10:24, 23 December 2020	DeSl	Ontology Term : 'prolidase deficiency' added !
	114126	view	10:24, 23 December 2020	DeSl	Ontology Term : 'hyperprolinemia' added !
	114125	view	10:24, 23 December 2020	DeSl	Ontology Term : 'hyperprolinemia type 2' added !
	114124	view	10:24, 23 December 2020	DeSl	Ontology Term : 'hyperprolinemia type II pathway' added !
	114123	view	10:24, 23 December 2020	DeSl	Ontology Term : 'hyperprolinemia type I pathway' added !
	114122	view	10:23, 23 December 2020	DeSl	Ontology Term : 'hyperprolinemia type 1' added !
	114121	view	10:23, 23 December 2020	DeSl	Ontology Term : 'arginine and proline metabolic pathway' added !
	114120	view	10:22, 23 December 2020	DeSl	Ontology Term : 'proline metabolic pathway' added !
	114119	view	10:22, 23 December 2020	DeSl	Ontology Term : 'glutathione synthase deficiency pathway' added !
	114090	view	07:28, 22 December 2020	Egonw	Remove RHEA: prefix in identifier
	114062	view	15:01, 18 December 2020	DeSl	Updated layout of disease interactions, added legend
	114061	view	14:58, 18 December 2020	DeSl	Updated description
	114060	view	14:52, 18 December 2020	DeSl	Added disorders (including OMIM ID); annotated some proteins
	114059	view	14:34, 18 December 2020	DeSl	Started adding IDs
	114052	view	12:55, 18 December 2020	DeSl	Added remaining steps
	114049	view	12:44, 18 December 2020	DeSl	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ALDH4A1	Protein
ASA	Metabolite	CHEBI:57472 (ChEBI)	aka argininosuccinic acid
FAD	Metabolite
FADH2	Metabolite
H+	Metabolite
NAD+	Metabolite
NADP	Metabolite
NADPH	Metabolite
NH3	Metabolite
OAT	Protein
OAT	Protein	P04181 (Uniprot-TrEMBL)
OH-proline	Metabolite
P5C	Metabolite	CHEBI:17388 (ChEBI)	aka delta1-pyrroline-5-carboxylate
P5CR	Protein		aka delta-1-pyrroline-5-carboxylate reductase
P5CS	Protein	P30038 (Uniprot-TrEMBL)	aka delta-1-pyrroline-5-carboxylate synthetase
PEPD	Protein
PRODH	Protein		aka proline dehydrogenase
X-OH-proline	Metabolite
X-proline	Metabolite
alanyl-proline	Metabolite
arginine	Metabolite	CHEBI:32682 (ChEBI)
citrulline	Metabolite	CHEBI:57743 (ChEBI)
collagen	Protein
delta1-pyrroline-3-hydroxy- 5-carboxylate	Metabolite
gamma-glutamyl-P	Metabolite
glutamate	Metabolite	CHEBI:29985 (ChEBI)
glutamic	Metabolite
glutamic-semialdehyde	Metabolite
glycyl-proline	Metabolite
ornithine	Metabolite	CHEBI:46911 (ChEBI)
proline	Metabolite	CHEBI:60039 (ChEBI)

Annotated Interactions

No annotated interactions