Mitochondrial complex I inhibition leading to parkinsonian motor deficits (Homo sapiens)

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1KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)MMP+Decreased mitochondrial oxidative phosphorylationAssembly of mitochondrial complex IImpaired proteostasisUnfolded Protein ResponseRotenoneKE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)KE177: N/A, Mitochondrial dysfunction 1KE889: Impaired, ProteostasisDegeneration of DA neurons of nigrostratial pathwayParkinsonian motor deficitsNeuroinflammationKE188: N/A, NeuroinflammationKE890: Degeneration of dopaminergic neurons of the nigrostriatal pathwayKE896: Parkinsonian motor deficits


Description

This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway (AOP) of Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits AOP-Wiki:3. All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, Leist M, Schildknecht S; ''An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.''; Arch Toxicol, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137837view14:02, 8 March 2025EweitzFix layering, align nodes
137836view14:00, 8 March 2025EweitzEconomize layout
137794view06:27, 8 March 2025EgonwModified description
118497view09:10, 28 May 2021FinterlyReplaced DataNode type "Key Event" and "Stressor" with "Event"
116641view11:30, 9 May 2021EweitzModified title
111510view09:58, 21 August 2020Marvin M2Ungrouped for nicer network merging
111507view09:51, 21 August 2020Marvin M2changed connections in groups
111425view11:32, 7 August 2020Marvin M2
111423view11:14, 7 August 2020Marvin M2Modified description
111422view11:13, 7 August 2020Marvin M2Added literature reference
111421view11:02, 7 August 2020Marvin M2Ontology Term : 'altered energy metabolic pathway' added !
111420view10:38, 7 August 2020Marvin M2Ontology Term : 'Parkinson's disease' added !
111419view10:37, 7 August 2020Marvin M2Ontology Term : 'DOID:0060897' removed !
111418view10:37, 7 August 2020Marvin M2Ontology Term : 'Parkinson disease 17' added !
111417view10:36, 7 August 2020Marvin M2Modified description
111078view13:48, 6 July 2020Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Assembly of mitochondrial complex IPathwayWP4324 (WikiPathways)
Decreased mitochondrial oxidative phosphorylationPathwayWP111 (WikiPathways)
Degeneration of DA neurons of nigrostratial pathwayPathwayWP2855 (WikiPathways)
Impaired proteostasisPathwayWP4918 (WikiPathways)
KE177: N/A, Mitochondrial dysfunction 1Key Event177 (AOP-Wiki KE)
KE188: N/A, NeuroinflammationKey Event188 (AOP-Wiki KE)
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)Key Event887 (AOP-Wiki KE)
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)Key Event888 (AOP-Wiki KE)
KE889: Impaired, Proteostasis Key Event889 (AOP-Wiki KE)
KE890: Degeneration of dopaminergic neurons of the nigrostriatal pathwayKey Event890 (AOP-Wiki KE)
KE896: Parkinsonian motor deficits896 (AOP-Wiki KE)
MMP+222 (AOP-Wiki Stressor)
NeuroinflammationPathwayWP4919 (WikiPathways)
Parkinsonian motor deficitsPathwayWP2371 (WikiPathways)
RotenoneStressor50 (AOP-Wiki Stressor)
Unfolded Protein ResponsePathwayWP4925 (WikiPathways)

Annotated Interactions

No annotated interactions

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