Direct reversal repair (Homo sapiens)

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Damaged base with CH2OH groupMGMTALKBH3ALKBH25'5'3'3'5'5'3'3'5'5'3'3'Native DNADamaged base with CH3 group


Description

draft

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Quality Tags

Ontology Terms

 

Bibliography

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  1. ''Direct reversal repair''; REPAIRtoire,
  2. Fang Q; ''The Versatile Attributes of MGMT: Its Repair Mechanism, Crosstalk with Other DNA Repair Pathways, and Its Role in Cancer.''; Cancers (Basel), 2024 PubMed Europe PMC Scholia
  3. Kanazhevskaya LY, Smyshliaev DA, Timofeyeva NA, Ishchenko AA, Saparbaev M, Kuznetsov NA, Fedorova OS; ''Conformational Dynamics of Human ALKBH2 Dioxygenase in the Course of DNA Repair as Revealed by Stopped-Flow Fluorescence Spectroscopy.''; Molecules, 2022 PubMed Europe PMC Scholia
  4. Gutierrez R, O'Connor TR; ''DNA direct reversal repair and alkylating agent drug resistance.''; Cancer Drug Resist, 2021 PubMed Europe PMC Scholia
  5. Gutierrez R, Chan AYS, Lai SWT, Itoh S, Lee DH, Sun K, Battad A, Chen S, O'Connor TR, Shuck SC; ''Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation.''; J Biol Chem, 2024 PubMed Europe PMC Scholia
  6. You C, Wang P, Nay SL, Wang J, Dai X, O'Connor TR, Wang Y; ''Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions.''; ACS Chem Biol, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141432view11:53, 14 November 2025DeSlAdded refs for drie proteins individually, and two describing all three in relationship to PW title
141351view03:08, 11 November 2025EweitzClear cached dimensions
141350view03:08, 11 November 2025EweitzEconomize layout
136381view01:24, 1 February 2025KhanspersModified description
136380view01:23, 1 February 2025Khanspersupdated reference
136379view01:22, 1 February 2025KhanspersOntology Term : 'regulatory pathway' added !
136378view01:21, 1 February 2025Khanspersupdated color on object
136377view01:20, 1 February 2025Khanspersadded reference, added labels to groups
117699view12:21, 22 May 2021EweitzModified title
110595view06:09, 20 May 2020KhanspersOntology Term : 'DNA repair pathway' added !
110594view05:55, 20 May 2020KhanspersModified description
110593view05:39, 20 May 2020Khanspersdecreased board height
110592view05:39, 20 May 2020Khanspersdecreased board height
110591view05:38, 20 May 2020KhanspersNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
ALKBH2GeneProductENSG00000189046 (Ensembl)
ALKBH3GeneProductENSG00000166199 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP4931"
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