Ketogenesis and ketolysis (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Newman JC, Verdin E; ''β-Hydroxybutyrate: A Signaling Metabolite.''; Annu Rev Nutr, 2017 PubMed Europe PMC Scholia
2. Noebels JL, Avoli M, Rogawski MA, Olsen R, Delgado-Escueta A; ''Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.''; https://www.ncbi.nlm.nih.gov/books/NBK98219/figure/masino.f1/; National Center for Biotechnology Information (US), 2012
3. Olson AL, Pessin JE; ''Structure, function, and regulation of the mammalian facilitative glucose transporter gene family.''; Annu Rev Nutr, 1996 PubMed Europe PMC Scholia
4. Sharpe AJ, McKenzie M; ''Mitochondrial Fatty Acid Oxidation Disorders Associated with Short-Chain Enoyl-CoA Hydratase (ECHS1) Deficiency.''; Cells, 2018 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	140506	view	06:00, 3 September 2025	Egonw	CO₂
	137916	view	17:39, 10 March 2025	Khanspers	Modified description
	122056	view	13:30, 9 March 2022	SamDrabbe	Pathway annotation ketogenesis adjusted
	119118	view	08:48, 18 June 2021	Finterly	Added ISBN for book citation
	117768	view	13:29, 22 May 2021	Eweitz	Modified title
	108452	view	13:56, 20 December 2019	DeSl	Ontology Term : 'glial cell' added !
	108451	view	13:55, 20 December 2019	DeSl	Ontology Term : 'PW:0000002' removed !
	108450	view	13:55, 20 December 2019	DeSl	Ontology Term : 'ketone bodies degradation pathway' added !
	108449	view	13:54, 20 December 2019	DeSl	Ontology Term : 'ketone bodies metabolic pathway' added !
	108448	view	13:54, 20 December 2019	DeSl	Modified description
	108447	view	13:49, 20 December 2019	DeSl	Updated right side of PW.
	108446	view	13:25, 20 December 2019	DeSl	Updated middle part
	108445	view	13:03, 20 December 2019	DeSl	Started updating lefthand side of PW
	107929	view	21:23, 11 November 2019	Khanspers	connected interaction
	107914	view	10:03, 10 November 2019	Egonw	Missed one sec ChEBI ID :(
	107911	view	09:14, 10 November 2019	Egonw	Better representation for mediated translocations.
	107910	view	09:07, 10 November 2019	Egonw	Fixed two interactions, which are not conversions.
	107909	view	09:03, 10 November 2019	Egonw	Replaced secondary ChEBI identifiers with a primary identifiers.
	107901	view	19:32, 9 November 2019	RGrosmanC	Ontology Term : 'neuron' added !
	107900	view	19:32, 9 November 2019	RGrosmanC	Ontology Term : 'hepatocyte' added !
	107899	view	19:31, 9 November 2019	RGrosmanC	Ontology Term : 'classic metabolic pathway' added !
	107898	view	19:30, 9 November 2019	RGrosmanC	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
?	Protein
ACA	Metabolite	CHEBI:15344 (ChEBI)
ACAT2	GeneProduct	ENSG00000120437 (Ensembl)
ATP	Metabolite	CHEBI:15422 (ChEBI)
Acetoacetate	Metabolite	CHEBI:15344 (ChEBI)
Acetoacetyl-CoA	Metabolite	CHEBI:15345 (ChEBI)
Acetyl-CoA	Metabolite	CHEBI:15351 (ChEBI)
BDH1	GeneProduct	ENSG00000161267 (Ensembl)
BHB	Metabolite	CHEBI:37054 (ChEBI)	BHB aka β-hydroxybutyrate
CAT	Protein	O43772 (Uniprot-TrEMBL)	CAT aka carnitine translocase
CO2	Metabolite	CHEBI:16526 (ChEBI)
CPT-1	Protein	P23786 (Uniprot-TrEMBL)	CPT1 (mitochondrial isoform) aka carnitine palmitoyl transferase
FAO	Pathway	WP143 (WikiPathways)
FA	Metabolite	Q61476 (Wikidata)
Fatty acids (FA)	Metabolite	Q61476 (Wikidata)
GLUT-1	Protein	P11166 (Uniprot-TrEMBL)	Gene: SLC2A1
Gluconeogenesis	Pathway	WP4740 (WikiPathways)
Glycolysis	Pathway	WP4277 (WikiPathways)
Ketogenesis	Pathway	WP4741 (WikiPathways)
MCT-1	Protein	P53985 (Uniprot-TrEMBL)	Gene: SLC16A1
Mitochondrial LC-Fatty Acid Beta-Oxidation	Pathway	WP368 (WikiPathways)
OXCT1	GeneProduct	ENSG00000083720 (Ensembl)
Oxaloacetate	Metabolite	CHEBI:30744 (ChEBI)
TCA (Krebs)cycle	Pathway	WP78 (WikiPathways)
UCP2	GeneProduct	ENSG00000175567 (Ensembl)
acetone	Metabolite	CHEBI:15347 (ChEBI)
glucose	Metabolite	CHEBI:17234 (ChEBI)
pyruvate	Metabolite	CHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions