Platelet-mediated interactions with vascular and circulating cells (Homo sapiens)

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1MonocytePlateletEndothelial cellDCs become antigen presenting cellsRecruitment of leukocytesIncreased endothelialpermeabilityDengue, flu, CMVInflammatory SignalsInfectionActivation, differentiationIgG productionGranule contentreleaseFormation of Heterotypic Aggregates (HAGs)P-selectinSELEIL1BTLR2CD40TLR4TLR7Dendritic cellCD40VCAM1ICAM1PF4SerotoninCCL5TGFB1B cellEosinophilCD40LGEndothelial cellNeutrophilT cellNK cellPSGL1P-selectinPSGL1PSGL1CD40-LTLR4IL1BCCL2TGFB2TGFB3


Description

draft

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Ontology Terms

 

Bibliography

  1. Koupenova M, Clancy L, Corkrey HA, Freedman JE; ''Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis.''; Circ Res, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139061view05:01, 17 May 2025Khansperscell size
137761view18:46, 7 March 2025KhanspersModified description
134790view02:34, 27 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134789view01:34, 27 July 2024EweitzStandardize case, tailor node widths
134788view01:02, 27 July 2024EweitzOntology Term : 'B cell' added !
134787view01:02, 27 July 2024EweitzOntology Term : 'T cell' added !
134786view01:02, 27 July 2024EweitzOntology Term : 'natural killer cell' added !
134785view01:01, 27 July 2024EweitzOntology Term : 'professional antigen presenting cell' added !
134784view01:01, 27 July 2024EweitzOntology Term : 'endothelial cell' added !
134783view01:00, 27 July 2024EweitzOntology Term : 'leukocyte' added !
134782view01:00, 27 July 2024EweitzOntology Term : 'dendritic cell' added !
134781view01:00, 27 July 2024EweitzOntology Term : 'monocyte' added !
134780view00:59, 27 July 2024EweitzOntology Term : 'eosinophil' added !
134779view00:59, 27 July 2024EweitzOntology Term : 'neutrophil' added !
102079view19:26, 28 November 2018EgonwReplaced old Uniprot data sources with the new ones.
102059view21:41, 27 November 2018KhanspersModified description
102058view21:26, 27 November 2018Khanspersfinalized endothelial cell
102047view23:34, 26 November 2018Khanspersmoved PSGL1 to endothelial cell
102046view22:54, 26 November 2018Khanspersupdates based on feedback from original author
101971view14:01, 21 November 2018DeSlChanged secondary to primary ChEBI ID for serotonin.
101846view00:18, 13 November 2018KhanspersOntology Term : 'hemostasis pathway' added !
101845view00:18, 13 November 2018KhanspersOntology Term : 'platelet' added !
101844view00:18, 13 November 2018KhanspersOntology Term : 'thrombosis' added !
101843view00:17, 13 November 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCL2GeneProductENSG00000108691 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CD40-LProteinP29965 (Uniprot-TrEMBL)
CD40GeneProductENSG00000101017 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl)
CD40ProteinP25942 (Uniprot-TrEMBL)
ICAM1GeneProductENSG00000090339 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
P-selectinProteinP16109 (Uniprot-TrEMBL)
PF4GeneProductENSG00000163737 (Ensembl)
PSGL1ProteinQ14242 (Uniprot-SwissProt)
SELEGeneProductENSG00000007908 (Ensembl)
SerotoninMetaboliteCHEBI:28790 (ChEBI)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TLR2ProteinO60603 (Uniprot-TrEMBL)
TLR4ProteinO00206 (Uniprot-TrEMBL)
TLR7ProteinB2R9N9 (Uniprot-TrEMBL)
VCAM1GeneProductENSG00000162692 (Ensembl)

Annotated Interactions

No annotated interactions

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