Portal:CPTAC
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Revision as of 18:02, 3 October 2017
CPTAC Pathways
Welcome to the CPTAC Pathway PortalThis portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC). The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public. The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011. | 
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Cancer Hallmark Categories
| Sustaining proliferative signaling
Hippo-Merlin signaling dysregulation (Homo sapiens) Image does not exist Hippo-Merlin signaling dysregulation | Evading growth suppressors
TGF-beta signaling (Homo sapiens) Image does not exist TGF-beta signaling | Activating invasion and metastasis
Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens) Image does not exist Epithelial to mesenchymal transition in colorectal cancer |
| Enabling replicative immortality
Regulation of Wnt / B-catenin signaling by small molecule compounds (Homo sapiens) Image does not exist Regulation of Wnt / B-catenin signaling by small molecule compounds | Inducing angiogenesis
Angiogenesis (Homo sapiens) Image does not exist Angiogenesis | Resisting cell death
miRNA regulation of p53 pathway in prostate cancer (Homo sapiens) Image does not exist miRNA regulation of p53 pathway in prostate cancer |
| Deregulating cellular energetics
TCA cycle nutrient use and invasiveness of ovarian cancer (Homo sapiens) Image does not exist TCA cycle nutrient use and invasiveness of ovarian cancer | Genome instability and mutation
DNA IR-double strand breaks and cellular response via ATM (Homo sapiens) Image does not exist DNA IR-double strand breaks and cellular response via ATM | Tumor promoting inflammation
Chemokine signaling (Homo sapiens) Image does not exist Chemokine signaling |
| Avoiding immune destruction
Interferon type I signaling (Homo sapiens) Image does not exist Interferon type I signaling | Therapeutics
lncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens) Image does not exist lncRNA-mediated mechanisms of therapeutic resistance |
Featured Pathways
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Image does not exist PDGFR-beta pathway Zhang, et al. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer |
| View featured pathways |
| List of all pathways for this portal |
Pathway Curation
On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.
Getting Started
- Introduction to WikiPathways (slides)
- WikiPathways Overview or New Contributor Quickstart
- General help pages
- CPTAC Workshop Exercises
Resources
- Learn more about CPTAC
- Pathway analysis
- Cytoscape and the WikiPathways app
- PathVisio and the WikiPathways plugin
Curation projects
- Curating Hallmark Pathways -- How to
- Example: construction of Pathways in Renal Cancer
- Contact Alex Pico if interested in curating, adding or using CPTAC pathways, apico@gladstone.ucsf.edu
