Portal:CPTAC

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Revision as of 21:25, 9 August 2018

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Cancer Hallmark Categories

Sustaining proliferative signaling

Ras signaling (Homo sapiens)

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Ras signaling
Evading growth suppressors

Retinoblastoma gene in cancer (Homo sapiens)

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Retinoblastoma gene in cancer
Activating invasion and metastasis

TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition (Homo sapiens)

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TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition
Enabling replicative immortality

ncRNAs involved in STAT3 signaling in hepatocellular carcinoma (Homo sapiens)

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ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
Inducing angiogenesis

Angiogenesis (Homo sapiens)

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Angiogenesis
Resisting cell death

Target of rapamycin signaling (Homo sapiens)

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Target of rapamycin signaling
Deregulating cellular energetics

Fatty acid beta-oxidation (Homo sapiens)

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Fatty acid beta-oxidation
Genome instability and mutation

DNA damage response (only ATM dependent) (Homo sapiens)

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DNA damage response (only ATM dependent)
Tumor promoting inflammation

Chemokine signaling (Homo sapiens)

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Chemokine signaling
Avoiding immune destruction

Type II interferon signaling (Homo sapiens)

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Type II interferon signaling
Therapeutics

Imatinib and chronic myeloid leukemia (Homo sapiens)

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Imatinib and chronic myeloid leukemia

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

Learn how they incorpated WikiPathways images with custom links on their site.

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

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