Portal:CPTAC

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[[Category:Portals]]

Current revision

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Cancer Hallmark Categories

Sustaining proliferative signaling

MAPK signaling (Homo sapiens)

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MAPK signaling
Evading growth suppressors

Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (Homo sapiens)

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Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer
Activating invasion and metastasis

MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

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MFAP5-mediated ovarian cancer cell motility and invasiveness
Enabling replicative immortality

Regulation of Wnt / B-catenin signaling by small molecule compounds (Homo sapiens)

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Regulation of Wnt / B-catenin signaling by small molecule compounds
Inducing angiogenesis

Hedgehog signaling (Homo sapiens)

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Hedgehog signaling
Resisting cell death

TP53 network (Homo sapiens)

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TP53 network
Deregulating cellular energetics

Hereditary leiomyomatosis and renal cell carcinoma pathway (Homo sapiens)

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Hereditary leiomyomatosis and renal cell carcinoma pathway
Genome instability and mutation

DNA IR-damage and cellular response via ATR (Homo sapiens)

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DNA IR-damage and cellular response via ATR
Tumor promoting inflammation

Cytokines and inflammatory response (Homo sapiens)

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Cytokines and inflammatory response
Avoiding immune destruction

Type II interferon signaling (Homo sapiens)

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Type II interferon signaling
Therapeutics

Cancer immunotherapy by CTLA4 blockade (Homo sapiens)

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Cancer immunotherapy by CTLA4 blockade

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

Learn how they incorpated WikiPathways images with custom links on their site.

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Retrieved from "https://oldclassic.wikipathways.org/index.php/Portal:CPTAC"
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