User:Marvin M2/AOPportal/Mission - Revision history

Marvin M2 at 10:24, 31 March 2017

2017-03-31T10:24:58Z

←Older revision		Revision as of 10:24, 31 March 2017
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-	The purpose ~~behind the creation~~ of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open PHACTS Foundation] (OPF) is responsible for AOP creation. The subjects of the first AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.	+	The purpose of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open PHACTS Foundation] (OPF) is responsible for AOP creation. The subjects of the first AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.

Marvin M2 at 14:58, 30 March 2017

2017-03-30T14:58:13Z

←Older revision		Revision as of 14:58, 30 March 2017
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-	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open PHACTS Foundation] (OPF) is responsible for AOP creation. The ~~subject~~ of the first ~~set of~~ AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.	+	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open PHACTS Foundation] (OPF) is responsible for AOP creation. The subjects of the first AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.


-	The proposed list of the first set of AOPs ~~are based on the case studies of the EU-ToxRisk project~~:	+	The proposed list of the first set of AOPs to be created:

	* Inhibition of β-oxidation leads to liver steatosis		* Inhibition of β-oxidation leads to liver steatosis

Marvin M2 at 14:31, 30 March 2017

2017-03-30T14:31:02Z

←Older revision		Revision as of 14:31, 30 March 2017
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-	The proposed list of the first set of AOPs:	+	The proposed list of the first set of AOPs are based on the case studies of the EU-ToxRisk project:

	* Inhibition of β-oxidation leads to liver steatosis		* Inhibition of β-oxidation leads to liver steatosis

Marvin M2 at 14:27, 30 March 2017

2017-03-30T14:27:40Z

←Older revision		Revision as of 14:27, 30 March 2017
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	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open PHACTS Foundation] (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.		The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open PHACTS Foundation] (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.

-	The proposed list of the first set of AOPs is:	+
		+	The proposed list of the first set of AOPs:

	* Inhibition of β-oxidation leads to liver steatosis		* Inhibition of β-oxidation leads to liver steatosis
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	* CYP51 inhibition causes embryotoxicity		* CYP51 inhibition causes embryotoxicity
	* Epithelial damage leads to popcorn lung		* Epithelial damage leads to popcorn lung
		+

	Basic strategies and principles for general AOPs are described in this paper:		Basic strategies and principles for general AOPs are described in this paper:

	Villeneuve ''et al.'' (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. ''Toxicological Sciences'' [https://www.ncbi.nlm.nih.gov/pubmed/25466378 PubMed]		Villeneuve ''et al.'' (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. ''Toxicological Sciences'' [https://www.ncbi.nlm.nih.gov/pubmed/25466378 PubMed]

Marvin M2 at 14:27, 30 March 2017

2017-03-30T14:27:01Z

←Older revision		Revision as of 14:27, 30 March 2017
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	The proposed list of the first set of AOPs is:		The proposed list of the first set of AOPs is:

-	*	+	* Inhibition of β-oxidation leads to liver steatosis
-	*	+	* HDAC inhibition, folate antagonism, oxidative stress and foetus accumulation lead to teratogenicity
-	*	+	* Oxidative stress leads to hepatotoxicity
-	*	+	* Oxidative stress leads to nephrotoxicity
-	*	+	* Disturbance of the respiratory chain leads to mitotoxicity
-	*	+	* PPAR activation leads to hepatoxicity
-	*	+	* OAT overactivation leads to nephrotoxicity
-	*	+	* PXR activation leads to liver steatosis
-		+	* NAPQI production causes hepatotoxicity
		+	* MTP impairment leads to hepatotoxicity
		+	* CYP51 inhibition causes embryotoxicity
		+	* Epithelial damage leads to popcorn lung

	Basic strategies and principles for general AOPs are described in this paper:		Basic strategies and principles for general AOPs are described in this paper:

	Villeneuve ''et al.'' (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. ''Toxicological Sciences'' [https://www.ncbi.nlm.nih.gov/pubmed/25466378 PubMed]		Villeneuve ''et al.'' (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. ''Toxicological Sciences'' [https://www.ncbi.nlm.nih.gov/pubmed/25466378 PubMed]

Marvin M2 at 11:37, 30 March 2017

2017-03-30T11:37:52Z

←Older revision		Revision as of 11:37, 30 March 2017
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-	Basic strategies and principles for ~~genreal~~ AOPs are described in this paper:	+	Basic strategies and principles for general AOPs are described in this paper:

	Villeneuve ''et al.'' (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. ''Toxicological Sciences'' [https://www.ncbi.nlm.nih.gov/pubmed/25466378 PubMed]		Villeneuve ''et al.'' (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. ''Toxicological Sciences'' [https://www.ncbi.nlm.nih.gov/pubmed/25466378 PubMed]

Marvin M2 at 11:01, 30 March 2017

2017-03-30T11:01:06Z

←Older revision		Revision as of 11:01, 30 March 2017
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	*		*
	*		*
-

Egonw at 10:19, 30 March 2017

2017-03-30T10:19:36Z

←Older revision		Revision as of 10:19, 30 March 2017
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-	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open ~~Phacts~~ Foundation] (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.	+	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open PHACTS Foundation] (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.

	The proposed list of the first set of AOPs is:		The proposed list of the first set of AOPs is:

Marvin M2 at 09:40, 30 March 2017

2017-03-30T09:40:28Z

←Older revision		Revision as of 09:40, 30 March 2017
Line 1:		Line 1:
-	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which Open Phacts Foundation (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.	+	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which [http://www.openphactsfoundation.org/ Open Phacts Foundation] (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.

	The proposed list of the first set of AOPs is:		The proposed list of the first set of AOPs is:

Marvin M2 at 09:38, 30 March 2017

2017-03-30T09:38:53Z

←Older revision		Revision as of 09:38, 30 March 2017
Line 1:		Line 1:
-	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which Open Phacts Foundation is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.	+	The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the [http://www.eu-toxrisk.eu/ EU-ToxRisk] program, in which Open Phacts Foundation (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.

	The proposed list of the first set of AOPs is:		The proposed list of the first set of AOPs is: