https://oldclassic.wikipathways.org/index.php?action=history&feed=atom&title=Thread%3APathway_looks_great%21_%281%29 2026-06-20T23:00:52Z Revision history for this page on the wiki MediaWiki 1.13.1 https://oldclassic.wikipathways.org/index.php?title=Thread:Pathway_looks_great%21_%281%29&diff=85899&oldid=prev 2016-06-20T21:33:15Z

<p>New page: The pathway looks great! After reviewing the original figure, I have a few suggestions: - For the inhibition of Wnt in the extracellular space (DKK3 etc), it would preferred if the inhibit...</p> <p><b>New page</b></p><div>The pathway looks great! After reviewing the original figure, I have a few suggestions:<br /> - For the inhibition of Wnt in the extracellular space (DKK3 etc), it would preferred if the inhibition arrow pointed to a copy of Wnt in the extracellular space instead of to the binding arrow. That is a more direct way of representing the information. If you keep the current representation, you could use a dashed arrow instead.<br /> - The representation of the destruction complex (with APC/Axin) and how it binds to beta-catenin could be improved. The arrow going from FZD/LRP to beta-catenin should be removed, I think. And while the complex facilitates destruction of beta-catenin like you illustrated, it is doing so while bound to beta-catenin. So I think a representation that is more similar to the one in the figure is more correct, with beta-catenin as part of the complex, with an arrow pointing to a mim-degradation object.<br /> - Inside the nucleus, you could use a mim-transcription-translation arrow instead of the regular arrow.</div>

Khanspers