https://oldclassic.wikipathways.org/index.php?action=history&feed=atom&title=Thread%3APathway_Incorrect_%281%29 2026-06-20T17:48:52Z Revision history for this page on the wiki MediaWiki 1.13.1 https://oldclassic.wikipathways.org/index.php?title=Thread:Pathway_Incorrect_%281%29&diff=107312&oldid=prev 2019-09-20T09:25:44Z

<p>New page: I've worked on immune and interferon signaling for years and STAT2 isn't activated by IFNg signaling. STAT2 and ISGF3 complex (STAT1:STAT2:IRF9) formation is unique to type I IFN signalin...</p> <p><b>New page</b></p><div> I've worked on immune and interferon signaling for years and STAT2 isn't activated by IFNg signaling. STAT2 and ISGF3 complex (STAT1:STAT2:IRF9) formation is unique to type I IFN signaling IFNa/b). I've looked at the paper this pathway is based on and I think they made a mistake. STAT2 can be a transcriptional target of IFNG but is never a part of the signaling cascade.<br /> <br /> I guess one of the biggest weaknesses of community derived pathway resources is that lack of evidence/provenance for each link between molecules in the signaling cascade.</div>

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