Murine chenodeoxycholic acid - muricholic acid/ murideoxycholic acid pathway: bile salt deconjugation, secondary bile acid synthesis, reconjugation and sulfation (Mus musculus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Murine chenodeoxycholic acid - muricholic acid/ murideoxycholic acid pathway: bile salt deconjugation, secondary bile acid synthesis, reconjugation and sulfation" Version="2025-12-17" Organism="Mus musculus"> <Comment Source="WikiPathways-description">This pathway focuses on murine-specific transformations of CDCA-derived bile acids, in which hepatic CYP2C70 converts CDCA and UDCA into α and β muricholic acids (MCA), which are primary bile acids in mice and can be further epimerized (via 7 and 6 hydroxyl epimerization) and dehydroxylated by the gut microbiota to form secondary species such as murideoxycholic acid and ω MCA. In mice, these MCA derivatives and their conjugated and sulfated forms are cycled through the enterohepatic circulation: gut bacteria deconjugate and desulfate muricholic and CDCA-derived bile salts, while hepatocytes reconjugate and resulfate them via SLC27A5, BAAT and sulfotransferase 2A, leading to a bile acid pool that is more enriched in muricholic acids than in humans. To visually simplify the pathway diagram, the following convention was applied: (i) stacking multiple enzymes: when two or more enzymes catalyse the same conversion, their nodes are placed in a stacked position and their representative catalytic interactions may overlap, but they all possess a unique catalytic interaction to the corresponding conversion, computationally contributing effectively to the catalysed transformation. ------------------------------------------------------------------------- &gt;&gt; Metabolite and enzyme abbreviations used with their full common names: * αMCA: alpha-muricholic acid * TαMCA: Tauro-alpha-muricholic acid * GαMCA: Glyco-alpha-muricholic acid * βMCA: beta-muricholic acid * TβMCA: Tauro-beta-muricholic acid * GβMCA: Glyco-beta-muricholic acid * MDCA: Murideoxycholic acid * 6-oxoLCA: 6-oxolithocholic acid * HDCA: Hyodeoxycholic acid * ωMCA: omega-muricholic acid * GωMCA: Glyco-omega-muricholic acid * TωMCA: Tauro-omega-muricholic acid * CDCA: Chenodeoxycholic Acid * UDCA: Ursodeoxycholic acid (UDCA) * SULT2A1: Sulfotransferase 2A1 * BAAT: Bile acid-CoA:amino acid N-acyltransferase * SLC27A5: Bile acid-CoA synthethase * CYP2c70: Cytochrome P450 2C70: Bile acid 6beta-hydroxylase * HDHA_ECOLI: 7alpha-hydroxysteroid dehydrogenase, Escherichia coli * RUMGNA_02585: 7beta-hydroxysteroid dehydrogenase, Mediterraneibacter gnavus * 6αHSDH: 6alpha-hydroxysteroid dehydrogenase * 6βHSDH: 6beta-hydroxysteroid dehydrogenase * CBH_BIFLN : Bile salt hydrolase/transferase, Bifidobacterium longum * CBH_BIFL2 : Bile salt hydrolase/transferase, Bifidobacterium longum subsp. longum * A0A8F5DVT9_9FIRM : Choloylglycine hydrolase, Christensenella minuta * Secondary BA Synthesis(CDCA-LCA/UDCA): Pathway → Chenodeoxycholic acid – lithocholic acid/ursodeoxycholic acid pathway: bile salt deconjugation, secondary bile acid synthesis, reconjugation and sulfation * 7α-dehydroxylation: Pathway → 7α-dehydroxylation of cholic acid and chenodeoxycholic acid by 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